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Overview

Uniprot IDP20108
Protein NameThioredoxin-dependent peroxide reductase, mitochondrial
Gene NamePrdx3
OrganismMus musculus

Kla Sites from experimental identification

Position Flanking peptide
150 AWINTPRKNGGLGHM
254 ASKEYFEKVHQ****
92 ELSLDDFKGKYLVLF

Function

Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. Acts synergistically with MAP3K13 to regulate the activation of NF-kappa-B in the cytosol (By similarity). Required for the maintenance of physical strength (PubMed:27037278)

Protein Sequence

10 MAAAAGRLLW 20 SSVARHASAI 30 SRSISASTVL 40 RPVASRRTCL 50 TDILWSASAQ 60 GKSAFSTSSS 70 FHTPAVTQHA 80 PYFKGTAVVN 90 GEFKELSLDD 100 FKGKYLVLFF 110 YPLDFTFVCP 120 TEIVAFSDKA 130 NEFHDVNCEV 140 VAVSVDSHFS 150 HLAWINTPRK 160 NGGLGHMNIT 170 LLSDITKQIS 180 RDYGVLLESA 190 GIALRGLFII 200 DPNGVVKHLS 210 VNDLPVGRSV 220 EETLRLVKAF 230 QFVETHGEVC 240 PANWTPESPT 250 IKPSPTASKE YFEKVHQ

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005769 early endosome
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0043209 myelin sheath
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0032991 protein-containing complex
Molecular Function GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0019901 protein kinase binding
Molecular Function GO:0008379 thioredoxin peroxidase activity
Biological Process GO:0045454 cell redox homeostasis
Biological Process GO:0034599 cellular response to oxidative stress
Biological Process GO:0034614 cellular response to reactive oxygen species
Biological Process GO:0042744 hydrogen peroxide catabolic process
Biological Process GO:0001893 maternal placenta development
Biological Process GO:0007005 mitochondrion organization
Biological Process GO:0030099 myeloid cell differentiation
Biological Process GO:0043066 negative regulation of apoptotic process
Biological Process GO:0033673 negative regulation of kinase activity
Biological Process GO:0043524 negative regulation of neuron apoptotic process
Biological Process GO:0043123 positive regulation of canonical NF-kappaB signal transduction
Biological Process GO:0008284 positive regulation of cell population proliferation
Biological Process GO:0051881 regulation of mitochondrial membrane potential
Biological Process GO:0042542 response to hydrogen peroxide
Biological Process GO:0032496 response to lipopolysaccharide
Biological Process GO:0006979 response to oxidative stress

Reference

[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.

[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.