Search Results
Overview
| Uniprot ID | P20112 |
|---|---|
| Protein Name | SPARC |
| Gene Name | SPARC |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 126 | SCHFFATKCTLEGTK |
| 137 | EGTKKGHKLHLDYIG |
| 188 | NNNLLTEKQKLRVKK |
| 201 | KKIHENEKRLEAGDH |
Function
Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity (By similarity)
Protein Sequence
10
MRAWIFFLLC
20
LAGKALAAPQ
30
QEALPDETEV
40
VEETVAEVPV
50
GANPVQVEVG
60
EFDDGAEEAE
70
EEVVAENPCQ
80
NHHCKHGKVC
90
ELDENNSPMC
100
VCQDPTSCPA
110
PIGEFEKVCS
120
NDNKTFDSSC
130
HFFATKCTLE
140
GTKKGHKLHL
150
DYIGPCKYIP
160
PCLDSELTEF
170
PLRMRDWLKN
180
VLVTLYERDE
190
NNNLLTEKQK
200
LRVKKIHENE
210
KRLEAGDHPV
220
ELLARDFEKN
230
YNMYIFPVHW
240
QFGQLDQHPI
250
DGYLSHTELA
260
PLRAPLIPME
270
HCTTRFFQTC
280
DLDNDKYIAL
290
DEWAGCFGIK
300
EQDIDKDLVI
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005604 | basement membrane |
| Cellular Component | GO:0031012 | extracellular matrix |
| Cellular Component | GO:0005615 | extracellular space |
| Molecular Function | GO:0005509 | calcium ion binding |
| Biological Process | GO:0050807 | regulation of synapse organization |
| Biological Process | GO:0048752 | semicircular canal morphogenesis |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.