Search Results
Overview
| Uniprot ID | P20132 |
|---|---|
| Protein Name | L-serine dehydratase/L-threonine deaminase |
| Gene Name | SDS |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 226 | VAKALGVKTVGAQAL |
Function
Catalyzes the pyridoxal-phosphate-dependent dehydrative deamination of L-threonine and L-serine to ammonia and alpha-ketobutyrate and pyruvate, respectively
Protein Sequence
10
MMSGEPLHVK
20
TPIRDSMALS
30
KMAGTSVYLK
40
MDSAQPSGSF
50
KIRGIGHFCK
60
RWAKQGCAHF
70
VCSSAGNAGM
80
AAAYAARQLG
90
VPATIVVPST
100
TPALTIERLK
110
NEGATVKVVG
120
ELLDEAFELA
130
KALAKNNPGW
140
VYIPPFDDPL
150
IWEGHASIVK
160
ELKETLWEKP
170
GAIALSVGGG
180
GLLCGVVQGL
190
QEVGWGDVPV
200
IAMETFGAHS
210
FHAATTAGKL
220
VSLPKITSVA
230
KALGVKTVGA
240
QALKLFQEHP
250
IFSEVISDQE
260
AVAAIEKFVD
270
DEKILVEPAC
280
GAALAAVYSH
290
VIQKLQLEGN
300
LRTPLPSLVV
310
IVCGGSNISL
320
AQLRALKEQL
GMTNRLPK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Molecular Function | GO:0030170 | pyridoxal phosphate binding |
| Cellular Component | GO:0005829 | cytosol |
| Molecular Function | GO:0003941 | L-serine ammonia-lyase activity |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0004794 | threonine deaminase activity |
| Biological Process | GO:0006094 | gluconeogenesis |
| Biological Process | GO:0006565 | L-serine catabolic process |
| Biological Process | GO:0006567 | L-threonine catabolic process |
| Biological Process | GO:0006629 | lipid metabolic process |
| Biological Process | GO:0042866 | pyruvate biosynthetic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.