Search Results

Overview

Uniprot ID	P20152
Protein Name	Vimentin
Gene Name	Vim
Organism	Mus musculus

Kla Sites from experimental identification

Position	Flanking peptide
104	KNTRTNEKVELQELN
120	RFANYIDKVRFLEQQ
402	IEIATYRKLLEGEES
445	SKRTLLIKTVETRDG

Function

Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally. Plays a role in cell directional movement, orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Protects SCRIB from proteasomal degradation and facilitates its localization to intermediate filaments in a cell contact-mediated manner (By similarity). May promote axon outgrowth and motor fiber repair via DSP-mediated recruitment to outgrowth tips (PubMed:25496840)

Protein Sequence

10 MSTRSVSSSS 20 YRRMFGGSGT 30 SSRPSSNRSY 40 VTTSTRTYSL 50 GSALRPSTSR 60 SLYSSSPGGA 70 YVTRSSAVRL 80 RSSVPGVRLL 90 QDSVDFSLAD 100 AINTEFKNTR 110 TNEKVELQEL 120 NDRFANYIDK 130 VRFLEQQNKI 140 LLAELEQLKG 150 QGKSRLGDLY 160 EEEMRELRRQ 170 VDQLTNDKAR 180 VEVERDNLAE 190 DIMRLREKLQ 200 EEMLQREEAE 210 STLQSFRQDV 220 DNASLARLDL 230 ERKVESLQEE 240 IAFLKKLHDE 250 EIQELQAQIQ 260 EQHVQIDVDV 270 SKPDLTAALR 280 DVRQQYESVA 290 AKNLQEAEEW 300 YKSKFADLSE 310 AANRNNDALR 320 QAKQESNEYR 330 RQVQSLTCEV 340 DALKGTNESL 350 ERQMREMEEN 360 FALEAANYQD 370 TIGRLQDEIQ 380 NMKEEMARHL 390 REYQDLLNVK 400 MALDIEIATY 410 RKLLEGEESR 420 ISLPLPTFSS 430 LNLRETNLES 440 LPLVDTHSKR 450 TLLIKTVETR 460 DGQVINETSQ HHDDLE

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0030424	axon
Cellular Component	GO:0044297	cell body
Cellular Component	GO:0031252	cell leading edge
Cellular Component	GO:0042995	cell projection
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005856	cytoskeleton
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005882	intermediate filament
Cellular Component	GO:0045111	intermediate filament cytoskeleton
Cellular Component	GO:0043005	neuron projection
Cellular Component	GO:0016363	nuclear matrix
Cellular Component	GO:0048471	perinuclear region of cytoplasm
Cellular Component	GO:0005777	peroxisome
Cellular Component	GO:0045335	phagocytic vesicle
Cellular Component	GO:0005886	plasma membrane
Cellular Component	GO:0045098	type III intermediate filament
Molecular Function	GO:0003725	double-stranded RNA binding
Molecular Function	GO:0042802	identical protein binding
Molecular Function	GO:1990254	keratin filament binding
Molecular Function	GO:0019900	kinase binding
Molecular Function	GO:0060090	molecular adaptor activity
Molecular Function	GO:0019904	protein domain specific binding
Molecular Function	GO:0051721	protein phosphatase 2A binding
Molecular Function	GO:1990782	protein tyrosine kinase binding
Molecular Function	GO:0003723	RNA binding
Molecular Function	GO:0097110	scaffold protein binding
Molecular Function	GO:0005200	structural constituent of cytoskeleton
Molecular Function	GO:0005212	structural constituent of eye lens
Biological Process	GO:0014002	astrocyte development
Biological Process	GO:0060020	Bergmann glial cell differentiation
Biological Process	GO:0071222	cellular response to lipopolysaccharide
Biological Process	GO:0071225	cellular response to muramyl dipeptide
Biological Process	GO:0071346	cellular response to type II interferon
Biological Process	GO:0045109	intermediate filament organization
Biological Process	GO:0045103	intermediate filament-based process
Biological Process	GO:0070307	lens fiber cell development
Biological Process	GO:0010977	negative regulation of neuron projection development
Biological Process	GO:0032967	positive regulation of collagen biosynthetic process
Biological Process	GO:0010634	positive regulation of epithelial cell migration
Biological Process	GO:0010628	positive regulation of gene expression
Biological Process	GO:0060252	positive regulation of glial cell proliferation
Biological Process	GO:0050770	regulation of axonogenesis
Biological Process	GO:0043488	regulation of mRNA stability
Biological Process	GO:1900147	regulation of Schwann cell migration

Reference

[1] Sung E, Sim H, Cho YC, Lee W, Bae JS et al.. Global Profiling of Lysine Acetylation and Lactylation in Kupffer Cells.. J Proteome Res 22(12):3683-3691. 2023 Dec 1. PMID: 37897433.

[2] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.

[3] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.

[4] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.