Search Results
Overview
| Uniprot ID | P20155 |
|---|---|
| Protein Name | Serine protease inhibitor Kazal-type 2 |
| Gene Name | SPINK2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 77 | REGGHNIKIIRNGPC |
Function
As a strong inhibitor of acrosin, it is required for normal spermiogenesis. It probably hinders premature activation of proacrosin and other proteases, thus preventing the cascade of events leading to spermiogenesis defects (PubMed:28554943). May be involved in the regulation of serine protease-dependent germ cell apoptosis (By similarity). It also inhibits trypsin
Protein Sequence
10
MALSVLRLAL
20
LLLAVTFAAS
30
LIPQFGLFSK
40
YRTPNCSQYR
50
LPGCPRHFNP
60
VCGSDMSTYA
70
NECTLCMKIR
80
EGGHNIKIIR
NGPC
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0001669 | acrosomal vesicle |
| Cellular Component | GO:0005576 | extracellular region |
| Molecular Function | GO:0004866 | endopeptidase inhibitor activity |
| Molecular Function | GO:0004867 | serine-type endopeptidase inhibitor activity |
| Biological Process | GO:0001675 | acrosome assembly |
| Biological Process | GO:0007286 | spermatid development |
Reference
[1] Yan M, Tu H, Tang S, Gai Z, Shi Q et al.. Lactylated Proteomic Analysis Reveals Functional Implications of Lysine Lactylation In Asthenozoospermia.. Mol Cell Proteomics 24(12):101439. 2025 Dec. PMID: 41192556.