Search Results

Overview

Uniprot IDP20248
Protein NameCyclin-A2
Gene NameCCNA2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
54 RAALAVLKSGNPRGL
68 LAQQQRPKTRRVAPL

Function

Essential for the control of the cell cycle at G1/S and G2/M transition (PubMed:1312467). Functions through the formation of specific serine/threonine protein kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 or CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle (PubMed:41100585)

Protein Sequence

10 MLGNSAPGPA 20 TREAGSALLA 30 LQQTALQEDQ 40 ENINPEKAAP 50 VQQPRTRAAL 60 AVLKSGNPRG 70 LAQQQRPKTR 80 RVAPLKDLPV 90 NDEHVTVPPW 100 KANSKQPAFT 110 IHVDEAEKEA 120 QKKPAESQKI 130 EREDALAFNS 140 AISLPGPRKP 150 LVPLDYPMDG 160 SFESPHTMDM 170 SIILEDEKPV 180 SVNEVPDYHE 190 DIHTYLREME 200 VKCKPKVGYM 210 KKQPDITNSM 220 RAILVDWLVE 230 VGEEYKLQNE 240 TLHLAVNYID 250 RFLSSMSVLR 260 GKLQLVGTAA 270 MLLASKFEEI 280 YPPEVAEFVY 290 ITDDTYTKKQ 300 VLRMEHLVLK 310 VLTFDLAAPT 320 VNQFLTQYFL 330 HQQPANCKVE 340 SLAMFLGELS 350 LIDADPYLKY 360 LPSVIAGAAF 370 HLALYTVTGQ 380 SWPESLIRKT 390 GYTLESLKPC 400 LMDLHQTYLK 410 APQHAQQSIR 420 EKYKNSKYHG 430 VSLLNPPETL NL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0097124 cyclin A2-CDK2 complex
Cellular Component GO:0000307 cyclin-dependent protein kinase holoenzyme complex
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0001939 female pronucleus
Cellular Component GO:0001940 male pronucleus
Cellular Component GO:0005815 microtubule organizing center
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity
Molecular Function GO:0019904 protein domain specific binding
Molecular Function GO:0019901 protein kinase binding
Biological Process GO:0031100 animal organ regeneration
Biological Process GO:0044843 cell cycle G1/S phase transition
Biological Process GO:0051301 cell division
Biological Process GO:0071314 cellular response to cocaine
Biological Process GO:0071392 cellular response to estradiol stimulus
Biological Process GO:0071456 cellular response to hypoxia
Biological Process GO:1990314 cellular response to insulin-like growth factor stimulus
Biological Process GO:0044320 cellular response to leptin stimulus
Biological Process GO:0071373 cellular response to luteinizing hormone stimulus
Biological Process GO:0071732 cellular response to nitric oxide
Biological Process GO:0036120 cellular response to platelet-derived growth factor stimulus
Biological Process GO:0090102 cochlea development
Biological Process GO:0000082 G1/S transition of mitotic cell cycle
Biological Process GO:0000086 G2/M transition of mitotic cell cycle
Biological Process GO:2000573 positive regulation of DNA biosynthetic process
Biological Process GO:0048146 positive regulation of fibroblast proliferation
Biological Process GO:0043687 post-translational protein modification
Biological Process GO:0007265 Ras protein signal transduction
Biological Process GO:0006275 regulation of DNA replication
Biological Process GO:0033762 response to glucagon

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[4] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[5] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.