Search Results

Overview

Uniprot IDP20290
Protein NameTranscription factor BTF3
Gene NameBTF3
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
171 RLAEALPKQSVDGKA
54 ETIMNQEKLAKLQAQ
57 MNQEKLAKLQAQVRI
86 RTATADDKKLQFSLK
87 TATADDKKLQFSLKK
93 KKLQFSLKKLGVNNI

Function

When associated with NACA, prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. BTF3 is also a general transcription factor that can form a stable complex with RNA polymerase II. Required for the initiation of transcription

Protein Sequence

10 MRRTGAPAQA 20 DSRGRGRARG 30 GCPGGEATLS 40 QPPPRGGTRG 50 QEPQMKETIM 60 NQEKLAKLQA 70 QVRIGGKGTA 80 RRKKKVVHRT 90 ATADDKKLQF 100 SLKKLGVNNI 110 SGIEEVNMFT 120 NQGTVIHFNN 130 PKVQASLAAN 140 TFTITGHAET 150 KQLTEMLPSI 160 LNQLGADSLT 170 SLRRLAEALP 180 KQSVDGKAPL 190 ATGEDDDDEV 200 PDLVENFDEA SKNEAN

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005854 nascent polypeptide-associated complex
Cellular Component GO:0005634 nucleus
Molecular Function GO:0003723 RNA binding
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:1905551 negative regulation of protein localization to endoplasmic reticulum
Biological Process GO:0015031 protein transport

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.