Search Results

Overview

Uniprot IDP20305
Protein NameGelsolin
Gene NameGSN
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
167 GGVASGFKHVVPNEV
183 VQRLFQVKGRRVVRA
235 LKATQVSKGIRDNER
328 CFILDHGKDGKIFVW
331 LDHGKDGKIFVWKGK
336 DGKIFVWKGKQANTE
350 EERKAALKTASDFIS
665 RLFACSNKIGRFVVE
718 TEALTSAKRYIETDP

Function

Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed (By similarity). Plays a role in ciliogenesis (By similarity)

Protein Sequence

10 LGALVVALCA 20 LSPPARAATA 30 SRGAPQARAP 40 QGRVSPMRPS 50 TMVVEHPEFL 60 KAGKEPGLQI 70 WRVEKFDLVP 80 VPPNLYGDFF 90 TGDAYVILKT 100 VQLRNGNLQY 110 DLHYWLGNEC 120 SQDESGAAAI 130 FTVQLDDYLN 140 GRAVQHREVQ 150 GFESATFLGY 160 FKSGLKYKKG 170 GVASGFKHVV 180 PNEVAVQRLF 190 QVKGRRVVRA 200 TEVPVSWESF 210 NRGDCFILDL 220 GNDIYQWCGS 230 NSNRYERLKA 240 TQVSKGIRDN 250 ERSGRAHVHV 260 SEEDAEPAGM 270 LQVLGPKPTL 280 PEGTEDTVKE 290 DAANRKLAKL 300 YKVSNGAGTM 310 TVSLVADENP 320 FAQGALKSED 330 CFILDHGKDG 340 KIFVWKGKQA 350 NTEERKAALK 360 TASDFISKMN 370 YPKQTQVSVL 380 PEGGETPLFK 390 QFFKNWRDPD 400 QVDGPGLSYL 410 SSHIANVERV 420 PFDAATLHTS 430 TAMAAQHGMD 440 DDGTGQKQIW 450 RIEGSNKVPV 460 DPATYGQFYG 470 GDSYIILYNY 480 RHGGRQGQII 490 YNWQGAQSTQ 500 DEVAASAILT 510 AQLDEELGGT 520 PVQSRVVQGK 530 EPAHLMSLFG 540 GKPMIIYRGG 550 TSREGGQTAP 560 ASTRLFQVRA 570 SSSGATRAVE 580 VIPKAGALNS 590 NDAFVLKTPS 600 AAYLWVGTGA 610 SEAEKTGAQE 620 LLRVLRAQPV 630 QVAEGSEPDS 640 FWEALGGKAA 650 YRTSPRLKDK 660 KMDAHPPRLF 670 ACSNKIGRFV 680 VEEVPGELMQ 690 EDLATDDVML 700 LDTWDQVFVW 710 VGKDSQEEEK 720 TEALTSAKRY 730 IETDPANRDR 740 RTPINVVKQG 750 FEPPSFVGWF 760 LGWDDNYWSV 770 DPLDRAIAEL AA

Gene Ontology

Classification GO ID Description
Cellular Component GO:0015629 actin cytoskeleton
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005576 extracellular region
Cellular Component GO:0005615 extracellular space
Molecular Function GO:0051015 actin filament binding
Molecular Function GO:0046872 metal ion binding
Molecular Function GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
Biological Process GO:0030042 actin filament depolymerization
Biological Process GO:0030041 actin filament polymerization
Biological Process GO:0051014 actin filament severing
Biological Process GO:0008154 actin polymerization or depolymerization
Biological Process GO:0051016 barbed-end actin filament capping
Biological Process GO:0030031 cell projection assembly
Biological Process GO:0007417 central nervous system development
Biological Process GO:0060271 cilium assembly

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.