Overview
| Uniprot ID | P20340 |
|---|
| Protein Name | Ras-related protein Rab-6A |
|---|
| Gene Name | RAB6A |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 164 |
AKAGYNVKQLFRRVA |
Function
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:25962623). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:25962623). RAB6A acts as a regulator of COPI-independent retrograde transport from the Golgi apparatus towards the endoplasmic reticulum (ER) (PubMed:25962623). Has a low GTPase activity (PubMed:25962623). Recruits VPS13B to the Golgi membrane (PubMed:25492866). Plays a role in neuron projection development (Probable)
Protein Sequence
10
MSTGGDFGNP
20
LRKFKLVFLG
30
EQSVGKTSLI
40
TRFMYDSFDN
50
TYQATIGIDF
60
LSKTMYLEDR
70
TVRLQLWDTA
80
GQERFRSLIP
90
SYIRDSTVAV
100
VVYDITNVNS
110
FQQTTKWIDD
120
VRTERGSDVI
130
IMLVGNKTDL
140
ADKRQVSIEE
150
GERKAKELNV
160
MFIETSAKAG
170
YNVKQLFRRV
180
AAALPGMEST
190
QDRSREDMID
200
IKLEKPQEQP
VSEGGCSC
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0002080 |
acrosomal membrane |
| Cellular Component |
GO:0036064 |
ciliary basal body |
| Cellular Component |
GO:0031410 |
cytoplasmic vesicle |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0012505 |
endomembrane system |
| Cellular Component |
GO:0005789 |
endoplasmic reticulum membrane |
| Cellular Component |
GO:0070381 |
endosome to plasma membrane transport vesicle |
| Cellular Component |
GO:0070062 |
extracellular exosome |
| Cellular Component |
GO:0005794 |
Golgi apparatus |
| Cellular Component |
GO:0000139 |
Golgi membrane |
| Cellular Component |
GO:0016020 |
membrane |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Cellular Component |
GO:0030667 |
secretory granule membrane |
| Cellular Component |
GO:0005802 |
trans-Golgi network |
| Cellular Component |
GO:0032588 |
trans-Golgi network membrane |
| Molecular Function |
GO:0003925 |
G protein activity |
| Molecular Function |
GO:0005525 |
GTP binding |
| Molecular Function |
GO:0003924 |
GTPase activity |
| Molecular Function |
GO:0031489 |
myosin V binding |
| Molecular Function |
GO:0019904 |
protein domain specific binding |
| Biological Process |
GO:0019882 |
antigen processing and presentation |
| Biological Process |
GO:0034498 |
early endosome to Golgi transport |
| Biological Process |
GO:0006891 |
intra-Golgi vesicle-mediated transport |
| Biological Process |
GO:0006886 |
intracellular protein transport |
| Biological Process |
GO:0072385 |
minus-end-directed organelle transport along microtubule |
| Biological Process |
GO:0031175 |
neuron projection development |
| Biological Process |
GO:0018125 |
peptidyl-cysteine methylation |
| Biological Process |
GO:0034067 |
protein localization to Golgi apparatus |
| Biological Process |
GO:1903292 |
protein localization to Golgi membrane |
| Biological Process |
GO:0042147 |
retrograde transport, endosome to Golgi |
| Biological Process |
GO:0006890 |
retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.