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Overview

Uniprot IDP20585
Protein NameDNA mismatch repair protein Msh3
Gene NameMSH3
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
226 KSANKRSKSIYTPLE
5 ***MSRRKPASGGLA

Function

Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta which binds to DNA mismatches thereby initiating DNA repair. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. MutS beta recognizes large insertion-deletion loops (IDL) up to 13 nucleotides long. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis

Protein Sequence

10 MSRRKPASGG 20 LAASSSAPAR 30 QAVLSRFFQS 40 TGSLKSTSSS 50 TGAADQVDPG 60 AAAAAAAAAA 70 AAPPAPPAPA 80 FPPQLPPHIA 90 TEIDRRKKRP 100 LENDGPVKKK 110 VKKVQQKEGG 120 SDLGMSGNSE 130 PKKCLRTRNV 140 SKSLEKLKEF 150 CCDSALPQSR 160 VQTESLQERF 170 AVLPKCTDFD 180 DISLLHAKNA 190 VSSEDSKRQI 200 NQKDTTLFDL 210 SQFGSSNTSH 220 ENLQKTASKS 230 ANKRSKSIYT 240 PLELQYIEMK 250 QQHKDAVLCV 260 ECGYKYRFFG 270 EDAEIAAREL 280 NIYCHLDHNF 290 MTASIPTHRL 300 FVHVRRLVAK 310 GYKVGVVKQT 320 ETAALKAIGD 330 NRSSLFSRKL 340 TALYTKSTLI 350 GEDVNPLIKL 360 DDAVNVDEIM 370 TDTSTSYLLC 380 ISENKENVRD 390 KKKGNIFIGI 400 VGVQPATGEV 410 VFDSFQDSAS 420 RSELETRMSS 430 LQPVELLLPS 440 ALSEQTEALI 450 HRATSVSVQD 460 DRIRVERMDN 470 IYFEYSHAFQ 480 AVTEFYAKDT 490 VDIKGSQIIS 500 GIVNLEKPVI 510 CSLAAIIKYL 520 KEFNLEKMLS 530 KPENFKQLSS 540 KMEFMTINGT 550 TLRNLEILQN 560 QTDMKTKGSL 570 LWVLDHTKTS 580 FGRRKLKKWV 590 TQPLLKLREI 600 NARLDAVSEV 610 LHSESSVFGQ 620 IENHLRKLPD 630 IERGLCSIYH 640 KKCSTQEFFL 650 IVKTLYHLKS 660 EFQAIIPAVN 670 SHIQSDLLRT 680 VILEIPELLS 690 PVEHYLKILN 700 EQAAKVGDKT 710 ELFKDLSDFP 720 LIKKRKDEIQ 730 GVIDEIRMHL 740 QEIRKILKNP 750 SAQYVTVSGQ 760 EFMIEIKNSA 770 VSCIPTDWVK 780 VGSTKAVSRF 790 HSPFIVENYR 800 HLNQLREQLV 810 LDCSAEWLDF 820 LEKFSEHYHS 830 LCKAVHHLAT 840 VDCIFSLAKV 850 AKQGDYCRPT 860 VQEERKIVIK 870 NGRHPVIDVL 880 LGEQDQYVPN 890 NTDLSEDSER 900 VMIITGPNMG 910 GKSSYIKQVA 920 LITIMAQIGS 930 YVPAEEATIG 940 IVDGIFTRMG 950 AADNIYKGQS 960 TFMEELTDTA 970 EIIRKATSQS 980 LVILDELGRG 990 TSTHDGIAIA 1000 YATLEYFIRD 1010 VKSLTLFVTH 1020 YPPVCELEKN 1030 YSHQVGNYHM 1040 GFLVSEDESK 1050 LDPGAAEQVP 1060 DFVTFLYQIT 1070 RGIAARSYGL 1080 NVAKLADVPG 1090 EILKKAAHKS 1100 KELEGLINTK 1110 RKRLKYFAKL 1120 WTMHNAQDLQ 1130 KWTEEFNMEE TQTSLLH

Gene Ontology

Classification GO ID Description
Cellular Component GO:0016020 membrane
Cellular Component GO:0032302 MutSbeta complex
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0140664 ATP-dependent DNA damage sensor activity
Molecular Function GO:0003690 double-stranded DNA binding
Molecular Function GO:0019899 enzyme binding
Molecular Function GO:0030983 mismatched DNA binding
Biological Process GO:0006281 DNA repair
Biological Process GO:0043570 maintenance of DNA repeat elements
Biological Process GO:0006298 mismatch repair
Biological Process GO:0006312 mitotic recombination
Biological Process GO:0045910 negative regulation of DNA recombination
Biological Process GO:0016447 somatic recombination of immunoglobulin gene segments

Reference

[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.