Search Results

Overview

Uniprot ID	P20591
Protein Name	Interferon-induced GTP-binding protein Mx1
Gene Name	MX1
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
197	QPADIGYKIKTLIKK

Function

Interferon-induced dynamin-like GTPase with antiviral activity against a wide range of RNA viruses and some DNA viruses. Its target viruses include negative-stranded RNA viruses and HBV through binding and inactivation of their ribonucleocapsid. May also antagonize reoviridae and asfarviridae replication. Inhibits thogoto virus (THOV) replication by preventing the nuclear import of viral nucleocapsids. Inhibits La Crosse virus (LACV) replication by sequestering viral nucleoprotein in perinuclear complexes, preventing genome amplification, budding, and egress. Inhibits influenza A virus (IAV) replication by decreasing or delaying NP synthesis and by blocking endocytic traffic of incoming virus particles. Enhances ER stress-mediated cell death after influenza virus infection. May regulate the calcium channel activity of TRPCs

Protein Sequence

10 MVVSEVDIAK 20 ADPAAASHPL 30 LLNGDATVAQ 40 KNPGSVAENN 50 LCSQYEEKVR 60 PCIDLIDSLR 70 ALGVEQDLAL 80 PAIAVIGDQS 90 SGKSSVLEAL 100 SGVALPRGSG 110 IVTRCPLVLK 120 LKKLVNEDKW 130 RGKVSYQDYE 140 IEISDASEVE 150 KEINKAQNAI 160 AGEGMGISHE 170 LITLEISSRD 180 VPDLTLIDLP 190 GITRVAVGNQ 200 PADIGYKIKT 210 LIKKYIQRQE 220 TISLVVVPSN 230 VDIATTEALS 240 MAQEVDPEGD 250 RTIGILTKPD 260 LVDKGTEDKV 270 VDVVRNLVFH 280 LKKGYMIVKC 290 RGQQEIQDQL 300 SLSEALQREK 310 IFFENHPYFR 320 DLLEEGKATV 330 PCLAEKLTSE 340 LITHICKSLP 350 LLENQIKETH 360 QRITEELQKY 370 GVDIPEDENE 380 KMFFLIDKVN 390 AFNQDITALM 400 QGEETVGEED 410 IRLFTRLRHE 420 FHKWSTIIEN 430 NFQEGHKILS 440 RKIQKFENQY 450 RGRELPGFVN 460 YRTFETIVKQ 470 QIKALEEPAV 480 DMLHTVTDMV 490 RLAFTDVSIK 500 NFEEFFNLHR 510 TAKSKIEDIR 520 AEQEREGEKL 530 IRLHFQMEQI 540 VYCQDQVYRG 550 ALQKVREKEL 560 EEEKKKKSWD 570 FGAFQSSSAT 580 DSSMEEIFQH 590 LMAYHQEASK 600 RISSHIPLII 610 QFFMLQTYGQ 620 QLQKAMLQLL 630 QDKDTYSWLL 640 KERSDTSDKR 650 KFLKERLARL 660 TQARRRLAQF PG

Gene Ontology

Classification	GO ID	Description
Biological Process	GO:0045087	innate immune response
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005789	endoplasmic reticulum membrane
Cellular Component	GO:0005874	microtubule
Cellular Component	GO:0031965	nuclear membrane
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0048471	perinuclear region of cytoplasm
Cellular Component	GO:0005886	plasma membrane
Cellular Component	GO:0098793	presynapse
Cellular Component	GO:0045202	synapse
Molecular Function	GO:0005525	GTP binding
Molecular Function	GO:0003924	GTPase activity
Molecular Function	GO:0042802	identical protein binding
Molecular Function	GO:0008017	microtubule binding
Biological Process	GO:0140374	antiviral innate immune response
Biological Process	GO:0006915	apoptotic process
Biological Process	GO:0006952	defense response
Biological Process	GO:0051607	defense response to virus
Biological Process	GO:0070106	interleukin-27-mediated signaling pathway
Biological Process	GO:0045071	negative regulation of viral genome replication
Biological Process	GO:0034340	response to type I interferon
Biological Process	GO:0009615	response to virus
Biological Process	GO:0007165	signal transduction
Biological Process	GO:0016185	synaptic vesicle budding from presynaptic endocytic zone membrane

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.