Search Results
Overview
| Uniprot ID | P20651 |
|---|---|
| Protein Name | Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform |
| Gene Name | Ppp3cb |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 172 | LTEYFTFKQECKIKY |
| 332 | NNKAAVLKYENNVMN |
| 56 | IPRVDVLKNHLVKEG |
| 61 | VLKNHLVKEGRVDEE |
Function
Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals. Dephosphorylates TFEB in response to lysosomal Ca(2+) release, resulting in TFEB nuclear translocation and stimulation of lysosomal biogenesis. Dephosphorylates and activates transcription factor NFATC1. Dephosphorylates and inactivates transcription factor ELK1. Dephosphorylates DARPP32 (By similarity). Negatively regulates MAP3K14/NIK signaling via inhibition of nuclear translocation of the transcription factors RELA and RELB (By similarity). May play a role in skeletal muscle fiber type specification (By similarity)
Protein Sequence
10
MAAPEPARAA
20
PPPPPPPPPP
30
LGADRVVKAV
40
PFPPTHRLTS
50
EEVFDMDGIP
60
RVDVLKNHLV
70
KEGRVDEEIA
80
LRIINEGAAI
90
LRREKTMIEV
100
EAPITVCGDI
110
HGQFFDLMKL
120
FEVGGSPANT
130
RYLFLGDYVD
140
RGYFSIECVL
150
YLWVLKILYP
160
STLFLLRGNH
170
ECRHLTEYFT
180
FKQECKIKYS
190
ERVYEACMEA
200
FDSLPLAALL
210
NQQFLCVHGG
220
LSPEIHTLDD
230
IRRLDRFKEP
240
PAFGPMCDLL
250
WSDPSEDFGN
260
EKSQEHFSHN
270
TVRGCSYFYN
280
YPAVCEFLQN
290
NNLLSIIRAH
300
EAQDAGYRMY
310
RKSQTTGFPS
320
LITIFSAPNY
330
LDVYNNKAAV
340
LKYENNVMNI
350
RQFNCSPHPY
360
WLPNFMDVFT
370
WSLPFVGEKV
380
TEMLVNVLSI
390
CSDDELMTEG
400
EDQFDVGSAA
410
ARKEIIRNKI
420
RAIGKMARVF
430
SVLREESESV
440
LTLKGLTPTG
450
MLPSGVLAGG
460
RQTLQSATVE
470
AIEAEKAIRG
480
SSPPHRICSF
490
EEAKGLDRIN
500
ERMPPRKDAV
510
QQDGFNSLNT
520
AHTTENHGTG
NHSAQ
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005955 | calcineurin complex |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0032991 | protein-containing complex |
| Cellular Component | GO:0045202 | synapse |
| Cellular Component | GO:0030315 | T-tubule |
| Cellular Component | GO:0030018 | Z disc |
| Molecular Function | GO:0005509 | calcium ion binding |
| Molecular Function | GO:0004723 | calcium-dependent protein serine/threonine phosphatase activity |
| Molecular Function | GO:0005516 | calmodulin binding |
| Molecular Function | GO:0033192 | calmodulin-dependent protein phosphatase activity |
| Molecular Function | GO:0019899 | enzyme binding |
| Molecular Function | GO:0046983 | protein dimerization activity |
| Molecular Function | GO:0030346 | protein phosphatase 2B binding |
| Molecular Function | GO:0004722 | protein serine/threonine phosphatase activity |
| Molecular Function | GO:0044877 | protein-containing complex binding |
| Biological Process | GO:0097720 | calcineurin-mediated signaling |
| Biological Process | GO:0033173 | calcineurin-NFAT signaling cascade |
| Biological Process | GO:0017156 | calcium-ion regulated exocytosis |
| Biological Process | GO:0007507 | heart development |
| Biological Process | GO:0031987 | locomotion involved in locomotory behavior |
| Biological Process | GO:0001946 | lymphangiogenesis |
| Biological Process | GO:0046716 | muscle cell cellular homeostasis |
| Biological Process | GO:0023057 | negative regulation of signaling |
| Biological Process | GO:0001915 | negative regulation of T cell mediated cytotoxicity |
| Biological Process | GO:0035774 | positive regulation of insulin secretion involved in cellular response to glucose stimulus |
| Biological Process | GO:1905673 | positive regulation of lysosome organization |
| Biological Process | GO:1900182 | positive regulation of protein localization to nucleus |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0006470 | protein dephosphorylation |
| Biological Process | GO:0006468 | protein phosphorylation |
| Biological Process | GO:0010468 | regulation of gene expression |
| Biological Process | GO:0050796 | regulation of insulin secretion |
| Biological Process | GO:1900242 | regulation of synaptic vesicle endocytosis |
| Biological Process | GO:0001975 | response to amphetamine |
| Biological Process | GO:0034097 | response to cytokine |
| Biological Process | GO:0006950 | response to stress |
| Biological Process | GO:0048741 | skeletal muscle fiber development |
| Biological Process | GO:0030217 | T cell differentiation |
| Biological Process | GO:0043029 | T cell homeostasis |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.