Search Results

Overview

Uniprot IDP20700
Protein NameLamin-B1
Gene NameLMNB1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
102 DTARERAKLQIELGK
109 KLQIELGKCKAEHDQ
111 QIELGKCKAEHDQLL
123 QLLLNYAKKESDLNG
156 LATALGDKKSLEGDL
157 ATALGDKKSLEGDLE
182 ASLAAAKKQLADETL
261 DAQVRLYKEELEQTY
271 LEQTYHAKLENARLS
312 SQLSNLQKESRACLE
389 EGEEERLKLSPSPSS
474 GGWEMIRKIGDTSVS
483 GDTSVSYKYTSRYVL
49 RLAVYIDKVRSLETE
532 EDVKVILKNSQGEEV

Function

Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:28716252, PubMed:32910914). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:28716252, PubMed:32910914). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:28716252, PubMed:32910914). Plays a role in sperm morphological development during late stages of spermiogenesis, particularly the anchoring of the sperm head to the tail (PubMed:38870534). Component of the LMNB1/SUN5/SEPT12 bridge that connects the sperm proximal centriole to the implantation fossa, the bridge functions to prevent detachment of the proximal centriole from the posterior nucleus during spermiogenesis (PubMed:38870534)

Protein Sequence

10 MATATPVPPR 20 MGSRAGGPTT 30 PLSPTRLSRL 40 QEKEELRELN 50 DRLAVYIDKV 60 RSLETENSAL 70 QLQVTEREEV 80 RGRELTGLKA 90 LYETELADAR 100 RALDDTARER 110 AKLQIELGKC 120 KAEHDQLLLN 130 YAKKESDLNG 140 AQIKLREYEA 150 ALNSKDAALA 160 TALGDKKSLE 170 GDLEDLKDQI 180 AQLEASLAAA 190 KKQLADETLL 200 KVDLENRCQS 210 LTEDLEFRKS 220 MYEEEINETR 230 RKHETRLVEV 240 DSGRQIEYEY 250 KLAQALHEMR 260 EQHDAQVRLY 270 KEELEQTYHA 280 KLENARLSSE 290 MNTSTVNSAR 300 EELMESRMRI 310 ESLSSQLSNL 320 QKESRACLER 330 IQELEDLLAK 340 EKDNSRRMLT 350 DKEREMAEIR 360 DQMQQQLNDY 370 EQLLDVKLAL 380 DMEISAYRKL 390 LEGEEERLKL 400 SPSPSSRVTV 410 SRASSSRSVR 420 TTRGKRKRVD 430 VEESEASSSV 440 SISHSASATG 450 NVCIEEIDVD 460 GKFIRLKNTS 470 EQDQPMGGWE 480 MIRKIGDTSV 490 SYKYTSRYVL 500 KAGQTVTIWA 510 ANAGVTASPP 520 TDLIWKNQNS 530 WGTGEDVKVI 540 LKNSQGEEVA 550 QRSTVFKTTI 560 PEEEEEEEEA 570 AGVVVEEELF 580 HQQGTPRASN RSCAIM

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005638 lamin filament
Cellular Component GO:0016020 membrane
Cellular Component GO:0005635 nuclear envelope
Cellular Component GO:0005637 nuclear inner membrane
Cellular Component GO:0005652 nuclear lamina
Cellular Component GO:0016363 nuclear matrix
Cellular Component GO:0031965 nuclear membrane
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0043274 phospholipase binding
Molecular Function GO:1990837 sequence-specific double-stranded DNA binding
Molecular Function GO:0005200 structural constituent of cytoskeleton
Molecular Function GO:0160123 structural constituent of nuclear lamina
Biological Process GO:0031507 heterochromatin formation
Biological Process GO:0006998 nuclear envelope organization
Biological Process GO:0007097 nuclear migration
Biological Process GO:0051664 nuclear pore localization
Biological Process GO:0090435 protein localization to nuclear envelope

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.