Search Results
Overview
| Uniprot ID | P20801 |
|---|---|
| Protein Name | Troponin C, skeletal muscle |
| Gene Name | Tnnc2 |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 137 | EEIESLMKDGDKNND |
| 91 | MKEDAKGKSEEELAE |
Function
Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments
Protein Sequence
10
MTDQQAEARS
20
YLSEEMIAEF
30
KAAFDMFDAD
40
GGGDISVKEL
50
GTVMRMLGQT
60
PTKEELDAII
70
EEVDEDGSGT
80
IDFEEFLVMM
90
VRQMKEDAKG
100
KSEEELAECF
110
RIFDRNADGY
120
IDAEELAEIF
130
RASGEHVTEE
140
EIESLMKDGD
150
KNNDGRIDFD
160
EFLKMMEGVQ
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005861 | troponin complex |
| Molecular Function | GO:0003779 | actin binding |
| Molecular Function | GO:0005509 | calcium ion binding |
| Biological Process | GO:0006937 | regulation of muscle contraction |
| Biological Process | GO:0003009 | skeletal muscle contraction |
Reference
[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.