Search Results
Overview
| Uniprot ID | P20823 |
|---|---|
| Protein Name | Hepatocyte nuclear factor 1-alpha |
| Gene Name | HNF1A |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 150 | HLSQHLNKGTPMKTQ |
Function
Transcriptional activator that regulates the tissue specific expression of multiple genes, especially in pancreatic islet cells and in liver (By similarity). Binds to the inverted palindrome 5'-GTTAATNATTAAC-3' (PubMed:10966642, PubMed:12453420). Activates the transcription of CYP1A2, CYP2E1 and CYP3A11 (By similarity)
Protein Sequence
10
MVSKLSQLQT
20
ELLAALLESG
30
LSKEALIQAL
40
GEPGPYLLAG
50
EGPLDKGESC
60
GGGRGELAEL
70
PNGLGETRGS
80
EDETDDDGED
90
FTPPILKELE
100
NLSPEEAAHQ
110
KAVVETLLQE
120
DPWRVAKMVK
130
SYLQQHNIPQ
140
REVVDTTGLN
150
QSHLSQHLNK
160
GTPMKTQKRA
170
ALYTWYVRKQ
180
REVAQQFTHA
190
GQGGLIEEPT
200
GDELPTKKGR
210
RNRFKWGPAS
220
QQILFQAYER
230
QKNPSKEERE
240
TLVEECNRAE
250
CIQRGVSPSQ
260
AQGLGSNLVT
270
EVRVYNWFAN
280
RRKEEAFRHK
290
LAMDTYSGPP
300
PGPGPGPALP
310
AHSSPGLPPP
320
ALSPSKVHGV
330
RYGQPATSET
340
AEVPSSSGGP
350
LVTVSTPLHQ
360
VSPTGLEPSH
370
SLLSTEAKLV
380
SAAGGPLPPV
390
STLTALHSLE
400
QTSPGLNQQP
410
QNLIMASLPG
420
VMTIGPGEPA
430
SLGPTFTNTG
440
ASTLVIGLAS
450
TQAQSVPVIN
460
SMGSSLTTLQ
470
PVQFSQPLHP
480
SYQQPLMPPV
490
QSHVTQSPFM
500
ATMAQLQSPH
510
ALYSHKPEVA
520
QYTHTGLLPQ
530
TMLITDTTNL
540
SALASLTPTK
550
QVFTSDTEAS
560
SESGLHTPAS
570
QATTLHVPSQ
580
DPASIQHLQP
590
AHRLSASPTV
600
SSSSLVLYQS
610
SDSSNGQSHL
620
LPSNHSVIET
630
FISTQMASSS
Q
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0000785 | chromatin |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0032991 | protein-containing complex |
| Molecular Function | GO:0003677 | DNA binding |
| Molecular Function | GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific |
| Molecular Function | GO:0003700 | DNA-binding transcription factor activity |
| Molecular Function | GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| Molecular Function | GO:0046983 | protein dimerization activity |
| Molecular Function | GO:0046982 | protein heterodimerization activity |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| Molecular Function | GO:0000976 | transcription cis-regulatory region binding |
| Biological Process | GO:0098708 | D-glucose import across plasma membrane |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0042593 | glucose homeostasis |
| Biological Process | GO:0030073 | insulin secretion |
| Biological Process | GO:0001889 | liver development |
| Biological Process | GO:0031016 | pancreas development |
| Biological Process | GO:0045893 | positive regulation of DNA-templated transcription |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0060261 | positive regulation of transcription initiation by RNA polymerase II |
| Biological Process | GO:0006357 | regulation of transcription by RNA polymerase II |
| Biological Process | GO:0035623 | renal D-glucose absorption |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.