Overview
| Uniprot ID | P20916 |
|---|
| Protein Name | Myelin-associated glycoprotein |
|---|
| Gene Name | MAG |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 497 |
ARNLYGAKSLELPFQ |
| 608 |
DLGKRPTKDSYTLTE |
Function
Adhesion molecule that mediates interactions between myelinating cells and neurons by binding to neuronal sialic acid-containing gangliosides and to the glycoproteins RTN4R and RTN4RL2 (By similarity). Not required for initial myelination, but seems to play a role in the maintenance of normal axon myelination. Protects motoneurons against apoptosis, also after injury; protection against apoptosis is probably mediated via interaction with neuronal RTN4R and RTN4RL2. Required to prevent degeneration of myelinated axons in adults; this probably depends on binding to gangliosides on the axon cell membrane (By similarity). Negative regulator of neurite outgrowth; in dorsal root ganglion neurons the inhibition is mediated primarily via binding to neuronal RTN4R or RTN4RL2 and to a lesser degree via binding to neuronal gangliosides. In cerebellar granule cells the inhibition is mediated primarily via binding to neuronal gangliosides. In sensory neurons, inhibition of neurite extension depends only partially on RTN4R, RTN4RL2 and gangliosides. Inhibits axon longitudinal growth (By similarity). Inhibits axon outgrowth by binding to RTN4R (By similarity). Preferentially binds to alpha-2,3-linked sialic acid. Binds ganglioside Gt1b (By similarity)
Protein Sequence
10
MIFLTALPLF
20
WIMISASRGG
30
HWGAWMPSSI
40
SAFEGTCVSI
50
PCRFDFPDEL
60
RPAVVHGVWY
70
FNSPYPKNYP
80
PVVFKSRTQV
90
VHESFQGRSR
100
LLGDLGLRNC
110
TLLLSNVSPE
120
LGGKYYFRGD
130
LGGYNQYTFS
140
EHSVLDIVNT
150
PNIVVPPEVV
160
AGTEVEVSCM
170
VPDNCPELRP
180
ELSWLGHEGL
190
GEPAVLGRLR
200
EDEGTWVQVS
210
LLHFVPTREA
220
NGHRLGCQAS
230
FPNTTLQFEG
240
YASMDVKYPP
250
VIVEMNSSVE
260
AIEGSHVSLL
270
CGADSNPPPL
280
LTWMRDGTVL
290
REAVAESLLL
300
ELEEVTPAED
310
GVYACLAENA
320
YGQDNRTVGL
330
SVMYAPWKPT
340
VNGTMVAVEG
350
ETVSILCSTQ
360
SNPDPILTIF
370
KEKQILSTVI
380
YESELQLELP
390
AVSPEDDGEY
400
WCVAENQYGQ
410
RATAFNLSVE
420
FAPVLLLESH
430
CAAARDTVQC
440
LCVVKSNPEP
450
SVAFELPSRN
460
VTVNESEREF
470
VYSERSGLVL
480
TSILTLRGQA
490
QAPPRVICTA
500
RNLYGAKSLE
510
LPFQGAHRLM
520
WAKIGPVGAV
530
VAFAILIAIV
540
CYITQTRRKK
550
NVTESPSFSA
560
GDNPPVLFSS
570
DFRISGAPEK
580
YESERRLGSE
590
RRLLGLRGEP
600
PELDLSYSHS
610
DLGKRPTKDS
620
YTLTEELAEY
AEIRVK
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0043218 |
compact myelin |
| Cellular Component |
GO:0045121 |
membrane raft |
| Cellular Component |
GO:0097453 |
mesaxon |
| Cellular Component |
GO:0043209 |
myelin sheath |
| Cellular Component |
GO:0035749 |
myelin sheath adaxonal region |
| Cellular Component |
GO:0033270 |
paranode region of axon |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Cellular Component |
GO:0043220 |
Schmidt-Lanterman incisure |
| Molecular Function |
GO:0030246 |
carbohydrate binding |
| Molecular Function |
GO:1905576 |
ganglioside GT1b binding |
| Molecular Function |
GO:0042803 |
protein homodimerization activity |
| Molecular Function |
GO:0019901 |
protein kinase binding |
| Molecular Function |
GO:0033691 |
sialic acid binding |
| Molecular Function |
GO:0005102 |
signaling receptor binding |
| Biological Process |
GO:0007155 |
cell adhesion |
| Biological Process |
GO:0098609 |
cell-cell adhesion |
| Biological Process |
GO:0071260 |
cellular response to mechanical stimulus |
| Biological Process |
GO:0032289 |
central nervous system myelin formation |
| Biological Process |
GO:0030517 |
negative regulation of axon extension |
| Biological Process |
GO:0043524 |
negative regulation of neuron apoptotic process |
| Biological Process |
GO:0045665 |
negative regulation of neuron differentiation |
| Biological Process |
GO:0010977 |
negative regulation of neuron projection development |
| Biological Process |
GO:0048711 |
positive regulation of astrocyte differentiation |
| Biological Process |
GO:0031643 |
positive regulation of myelination |
| Biological Process |
GO:0021762 |
substantia nigra development |
Reference
[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.