Search Results
Overview
| Uniprot ID | P20961 |
|---|---|
| Protein Name | Plasminogen activator inhibitor 1 |
| Gene Name | Serpine1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 145 | KLFRTTVKQVDFSEV |
| 168 | DWVERHTKGMISDLL |
| 51 | QHVVQASKDRNVVFS |
Function
Serine protease inhibitor. Inhibits TMPRSS7. Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots. As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading. Acts as a regulator of cell migration, independently of its role as protease inhibitor. It is required for stimulation of keratinocyte migration during cutaneous injury repair. It is involved in cellular and replicative senescence (By similarity). Plays a role in alveolar type 2 cells senescence in the lung (By similarity). Is involved in the regulation of cementogenic differentiation of periodontal ligament stem cells, and regulates odontoblast differentiation and dentin formation during odontogenesis (By similarity)
Protein Sequence
10
MQMSSALTCL
20
TLGLVLVFGK
30
GFASPLPESH
40
TAQQATNFGV
50
KVFQHVVQAS
60
KDRNVVFSPY
70
GVSSVLAMLQ
80
LTTAGKTRQQ
90
IQDAMGFNIS
100
ERGTAPALRK
110
LSKELMGSWN
120
KNEISTADAI
130
FVQRDLELVQ
140
GFMPHFFKLF
150
RTTVKQVDFS
160
EVERARFIIN
170
DWVERHTKGM
180
ISDLLAKGAV
190
NELTRLVLVN
200
ALYFNGQWKT
210
PFLEASTHQR
220
LFHKSDGSTI
230
SVPMMAQNNK
240
FNYTEFTTPD
250
GHEYDILELP
260
YHGETLSMFI
270
AAPFEKDVPL
280
SAITNILDAE
290
LIRQWKSNMT
300
RLPRLLILPK
310
FSLETEVDLR
320
GPLEKLGMTD
330
IFSSTQADFT
340
SLSDQEQLSV
350
AQALQKVKIE
360
VNESGTVASS
370
STAILVSARM
380
APTEMVLDRS
390
FLFVVRHNPT
400
ETILFMGQLM
EP
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0042583 | chromaffin granule |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0031012 | extracellular matrix |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:1904090 | peptidase inhibitor complex |
| Cellular Component | GO:0097180 | serine protease inhibitor complex |
| Molecular Function | GO:0004866 | endopeptidase inhibitor activity |
| Molecular Function | GO:0002020 | protease binding |
| Molecular Function | GO:0004867 | serine-type endopeptidase inhibitor activity |
| Molecular Function | GO:0005102 | signaling receptor binding |
| Biological Process | GO:0001525 | angiogenesis |
| Biological Process | GO:1904045 | cellular response to aldosterone |
| Biological Process | GO:1904385 | cellular response to angiotensin |
| Biological Process | GO:0071318 | cellular response to ATP |
| Biological Process | GO:0071320 | cellular response to cAMP |
| Biological Process | GO:0071321 | cellular response to cGMP |
| Biological Process | GO:0071409 | cellular response to cycloheximide |
| Biological Process | GO:0071549 | cellular response to dexamethasone stimulus |
| Biological Process | GO:0044344 | cellular response to fibroblast growth factor stimulus |
| Biological Process | GO:0071372 | cellular response to follicle-stimulating hormone stimulus |
| Biological Process | GO:0071377 | cellular response to glucagon stimulus |
| Biological Process | GO:0071333 | cellular response to glucose stimulus |
| Biological Process | GO:0071258 | cellular response to gravity |
| Biological Process | GO:0071363 | cellular response to growth factor stimulus |
| Biological Process | GO:0070301 | cellular response to hydrogen peroxide |
| Biological Process | GO:0071456 | cellular response to hypoxia |
| Biological Process | GO:0032869 | cellular response to insulin stimulus |
| Biological Process | GO:0071347 | cellular response to interleukin-1 |
| Biological Process | GO:1904637 | cellular response to ionomycin |
| Biological Process | GO:1990830 | cellular response to leukemia inhibitory factor |
| Biological Process | GO:0071222 | cellular response to lipopolysaccharide |
| Biological Process | GO:0071404 | cellular response to low-density lipoprotein particle stimulus |
| Biological Process | GO:0071260 | cellular response to mechanical stimulus |
| Biological Process | GO:0071248 | cellular response to metal ion |
| Biological Process | GO:1990090 | cellular response to nerve growth factor stimulus |
| Biological Process | GO:0071316 | cellular response to nicotine |
| Biological Process | GO:0036120 | cellular response to platelet-derived growth factor stimulus |
| Biological Process | GO:0035865 | cellular response to potassium ion |
| Biological Process | GO:1905835 | cellular response to pyrimidine ribonucleotide |
| Biological Process | GO:1904639 | cellular response to resveratrol |
| Biological Process | GO:0071560 | cellular response to transforming growth factor beta stimulus |
| Biological Process | GO:0071466 | cellular response to xenobiotic stimulus |
| Biological Process | GO:0046697 | decidualization |
| Biological Process | GO:0050829 | defense response to Gram-negative bacterium |
| Biological Process | GO:0097187 | dentinogenesis |
| Biological Process | GO:0008585 | female gonad development |
| Biological Process | GO:0045576 | mast cell activation |
| Biological Process | GO:0030195 | negative regulation of blood coagulation |
| Biological Process | GO:0033629 | negative regulation of cell adhesion mediated by integrin |
| Biological Process | GO:0030336 | negative regulation of cell migration |
| Biological Process | GO:0010951 | negative regulation of endopeptidase activity |
| Biological Process | GO:2000352 | negative regulation of endothelial cell apoptotic process |
| Biological Process | GO:1902042 | negative regulation of extrinsic apoptotic signaling pathway via death domain receptors |
| Biological Process | GO:0051918 | negative regulation of fibrinolysis |
| Biological Process | GO:0010629 | negative regulation of gene expression |
| Biological Process | GO:2001045 | negative regulation of integrin-mediated signaling pathway |
| Biological Process | GO:0010757 | negative regulation of plasminogen activation |
| Biological Process | GO:0045861 | negative regulation of proteolysis |
| Biological Process | GO:0014912 | negative regulation of smooth muscle cell migration |
| Biological Process | GO:2000098 | negative regulation of smooth muscle cell-matrix adhesion |
| Biological Process | GO:0070495 | negative regulation of thrombin-activated receptor signaling pathway |
| Biological Process | GO:0061044 | negative regulation of vascular wound healing |
| Biological Process | GO:0001890 | placenta development |
| Biological Process | GO:0045766 | positive regulation of angiogenesis |
| Biological Process | GO:0030194 | positive regulation of blood coagulation |
| Biological Process | GO:0090280 | positive regulation of calcium ion import |
| Biological Process | GO:0050820 | positive regulation of coagulation |
| Biological Process | GO:0032967 | positive regulation of collagen biosynthetic process |
| Biological Process | GO:1905043 | positive regulation of epithelium regeneration |
| Biological Process | GO:0048146 | positive regulation of fibroblast proliferation |
| Biological Process | GO:0010628 | positive regulation of gene expression |
| Biological Process | GO:0050729 | positive regulation of inflammatory response |
| Biological Process | GO:0032757 | positive regulation of interleukin-8 production |
| Biological Process | GO:0051549 | positive regulation of keratinocyte migration |
| Biological Process | GO:0035491 | positive regulation of leukotriene production involved in inflammatory response |
| Biological Process | GO:0090026 | positive regulation of monocyte chemotaxis |
| Biological Process | GO:1901331 | positive regulation of odontoblast differentiation |
| Biological Process | GO:0048260 | positive regulation of receptor-mediated endocytosis |
| Biological Process | GO:0045765 | regulation of angiogenesis |
| Biological Process | GO:0042127 | regulation of cell population proliferation |
| Biological Process | GO:0090399 | replicative senescence |
| Biological Process | GO:0034097 | response to cytokine |
| Biological Process | GO:0070849 | response to epidermal growth factor |
| Biological Process | GO:0043627 | response to estrogen |
| Biological Process | GO:0055093 | response to hyperoxia |
| Biological Process | GO:0034616 | response to laminar fluid shear stress |
| Biological Process | GO:0032496 | response to lipopolysaccharide |
| Biological Process | GO:0031667 | response to nutrient levels |
| Biological Process | GO:0000302 | response to reactive oxygen species |
| Biological Process | GO:0042594 | response to starvation |
| Biological Process | GO:0071559 | response to transforming growth factor beta |
| Biological Process | GO:0042246 | tissue regeneration |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.