Search Results
Overview
| Uniprot ID | P21107 |
|---|---|
| Protein Name | Tropomyosin alpha-3 chain |
| Gene Name | Tpm3 |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 150 | ELQEIQLKEAKHIAE |
| 214 | SLEAQAEKYSQKEDK |
Function
Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments
Protein Sequence
10
MMEAIKKKMQ
20
MLKLDKENVL
30
DRAEQAEAEQ
40
KQAEERSKQL
50
EDELATMQKK
60
LKGTEDELDK
70
YSEALKDAQE
80
KLELAEKKAA
90
DAEAEVASLN
100
RRIQLVEEEL
110
DRAQERLATA
120
LQKLEEAEKA
130
ADESERGMKV
140
IENRALKDEE
150
KMELQEIQLK
160
EAKHIAEEAD
170
RKYEEVARKL
180
VIIEGDLERT
190
EERAELAESK
200
CSELEEELKN
210
VTNNLKSLEA
220
QAEKYSQKED
230
KYEEEIKILT
240
DKLKEAETRA
250
EFAERSVAKL
260
EKTIDDLEDE
270
LYAQKLKYKA
280
ISDELDHALN
DMTSI
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0015629 | actin cytoskeleton |
| Cellular Component | GO:0005884 | actin filament |
| Cellular Component | GO:0032154 | cleavage furrow |
| Cellular Component | GO:0030863 | cortical cytoskeleton |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0030426 | growth cone |
| Cellular Component | GO:0043005 | neuron projection |
| Cellular Component | GO:0002102 | podosome |
| Cellular Component | GO:0001725 | stress fiber |
| Molecular Function | GO:0051015 | actin filament binding |
| Biological Process | GO:0007015 | actin filament organization |
| Biological Process | GO:0006936 | muscle contraction |
Reference
[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.
[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.