Overview
| Uniprot ID | P21127 |
|---|
| Protein Name | Cyclin-dependent kinase 11B |
|---|
| Gene Name | CDK11B |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 20 |
LDEILQEKKRRKEQE |
| 21 |
DEILQEKKRRKEQEE |
| 225 |
MREDYSDKVKASHWS |
| 424 |
ELKQELPKYLPALQG |
Function
Cyclin-dependent protein kinase that acts as a regulator of transcription and pre-mRNA splicing (PubMed:12501247, PubMed:18216018, PubMed:32367068, PubMed:36104565). Acts as a key regulator of pre-mRNA splicing by mediating phosphorylation of SF3B1, enabling the association between SF3B1 and U5 and U6 snRNAs in the activated spliceosome, thereby promoting spliceosome assembly (PubMed:36104565, PubMed:38059508). Also acts as a regulator of transcription by phosphorylating 'Ser-2' of the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A (PubMed:32367068, PubMed:40858114). Involved in replication-dependent transcription of histone genes: binds to histone genes and phosphorylates POLR2A at 'Ser-2' of the CTD to specifically control transcriptional elongation of histones and recruitment of 3'-end processing factors (PubMed:32367068). Part of a transcription checkpoint upstream of CDK9, which regulates promoter-proximal pausing by RNA polymerase II, a transcription halt following transcription initiation, but prior to elongation (PubMed:40858114). Probably regulates promoter-proximal pausing by mediating phosphorylation of POLR2A at 'Ser-2' of the CTD (PubMed:40858114). Activated by the CDK-activating kinase (CAK) complex consisting of CDK7, cyclin-H/CCNH and MAT1, which is a master regulator of CDK activity (PubMed:41100585)
Protein Sequence
10
MGDEKDSWKV
20
KTLDEILQEK
30
KRRKEQEEKA
40
EIKRLKNSDD
50
RDSKRDSLEE
60
GELRDHRMEI
70
TIRNSPYRRE
80
DSMEDRGEED
90
DSLAIKPPQQ
100
MSRKEKAHHR
110
KDEKRKEKRR
120
HRSHSAEGGK
130
HARVKEKERE
140
HERRKRHREE
150
QDKARREWER
160
QKRREMAREH
170
SRRERDRLEQ
180
LERKRERERK
190
MREQQKEQRE
200
QKERERRAEE
210
RRKEREARRE
220
VSAHHRTMRE
230
DYSDKVKASH
240
WSRSPPRPPR
250
ERFELGDGRK
260
PGEARPAPAQ
270
KPAQLKEEKM
280
EERDLLSDLQ
290
DISDSERKTS
300
SAESSSAESG
310
SGSEEEEEEE
320
EEEEEEGSTS
330
EESEEEEEEE
340
EEEEEETGSN
350
SEEASEQSAE
360
EVSEEEMSED
370
EERENENHLL
380
VVPESRFDRD
390
SGESEEAEEE
400
VGEGTPQSSA
410
LTEGDYVPDS
420
PALSPIELKQ
430
ELPKYLPALQ
440
GCRSVEEFQC
450
LNRIEEGTYG
460
VVYRAKDKKT
470
DEIVALKRLK
480
MEKEKEGFPI
490
TSLREINTIL
500
KAQHPNIVTV
510
REIVVGSNMD
520
KIYIVMNYVE
530
HDLKSLMETM
540
KQPFLPGEVK
550
TLMIQLLRGV
560
KHLHDNWILH
570
RDLKTSNLLL
580
SHAGILKVGD
590
FGLAREYGSP
600
LKAYTPVVVT
610
LWYRAPELLL
620
GAKEYSTAVD
630
MWSVGCIFGE
640
LLTQKPLFPG
650
KSEIDQINKV
660
FKDLGTPSEK
670
IWPGYSELPA
680
VKKMTFSEHP
690
YNNLRKRFGA
700
LLSDQGFDLM
710
NKFLTYFPGR
720
RISAEDGLKH
730
EYFRETPLPI
740
DPSMFPTWPA
750
KSEQQRVKRG
760
TSPRPPEGGL
770
GYSQLGDDDL
780
KETGFHLTTT
790
NQGASAAGPG
FSLKF
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005694 |
chromosome |
| Cellular Component |
GO:0000775 |
chromosome, centromeric region |
| Cellular Component |
GO:0180038 |
cyclin L-CDK11 complex |
| Cellular Component |
GO:0000307 |
cyclin-dependent protein kinase holoenzyme complex |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0016607 |
nuclear speck |
| Cellular Component |
GO:0005634 |
nucleus |
| Molecular Function |
GO:0005524 |
ATP binding |
| Molecular Function |
GO:0004693 |
cyclin-dependent protein serine/threonine kinase activity |
| Molecular Function |
GO:0004672 |
protein kinase activity |
| Molecular Function |
GO:0106310 |
protein serine kinase activity |
| Molecular Function |
GO:0004674 |
protein serine/threonine kinase activity |
| Molecular Function |
GO:0003723 |
RNA binding |
| Molecular Function |
GO:0140834 |
RNA polymerase II CTD heptapeptide repeat S2 kinase activity |
| Molecular Function |
GO:0140836 |
RNA polymerase II CTD heptapeptide repeat S5 kinase activity |
| Biological Process |
GO:0006915 |
apoptotic process |
| Biological Process |
GO:0000278 |
mitotic cell cycle |
| Biological Process |
GO:0071962 |
mitotic sister chromatid cohesion, centromeric |
| Biological Process |
GO:0006397 |
mRNA processing |
| Biological Process |
GO:0006468 |
protein phosphorylation |
| Biological Process |
GO:0042981 |
regulation of apoptotic process |
| Biological Process |
GO:0051726 |
regulation of cell cycle |
| Biological Process |
GO:0001558 |
regulation of cell growth |
| Biological Process |
GO:0046605 |
regulation of centrosome cycle |
| Biological Process |
GO:0006355 |
regulation of DNA-templated transcription |
| Biological Process |
GO:0050684 |
regulation of mRNA processing |
| Biological Process |
GO:0048024 |
regulation of mRNA splicing, via spliceosome |
| Biological Process |
GO:0001111 |
RNA polymerase II promoter clearance |
| Biological Process |
GO:0008380 |
RNA splicing |
Reference
PMID: N/A