Search Results
Overview
| Uniprot ID | P21263 |
|---|---|
| Protein Name | Nestin |
| Gene Name | Nes |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 1126 | EIARSLGKENQESLV |
| 1136 | QESLVSLKEKGIETV |
| 1138 | SLVSLKEKGIETVKS |
| 120 | RRALEAEKNARGWLS |
| 1219 | QELSSLGKWNVETRV |
| 1416 | GEESVKAKIAQGLEG |
| 1426 | QGLEGPGKEPKEAGA |
| 1596 | LRSPASPKWDLAGEQ |
| 547 | EEPLMSLKIQNYETA |
| 582 | KEKQIPLKSLEEKNV |
| 587 | PLKSLEEKNVESEKT |
| 622 | DQELMSPKGTLKRFS |
| 633 | KRFSSLGKESQEVVR |
| 643 | QEVVRPSKEGNLESW |
| 721 | ILERLIEKESQESLR |
| 853 | MLERLIEKESQESLK |
| 878 | PLERENQKSLRYLEE |
| 953 | NKSLLEDKTHKSLGS |
| 956 | LLEDKTHKSLGSLED |
Function
Required for brain and eye development (By similarity). Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells
Protein Sequence
10
MEGCVGEESF
20
QMWELNRRLE
30
AYLTRVKTLE
40
EQNQLLSAEL
50
GGLRAQSGDT
60
SWRARADDEL
70
ASLRILVDQR
80
WREKLEAEVQ
90
RDNLAEELES
100
VAGRCQQVRL
110
ARERTVQEAA
120
CSRRALEAEK
130
NARGWLSTQA
140
AELERELEAL
150
RAAHEEERAH
160
LNAQAACAPR
170
RPPAPPHGSP
180
VRAPEVEDLA
190
RRLGEVWRGA
200
VRDYQERVAH
210
MESSLGQARE
220
RLSQAVRGAR
230
ECRLEVQQLQ
240
ADRDSLQERR
250
EALEQRLEGR
260
WQDRLQATDK
270
FQLAVEALEQ
280
EKQGLQSQIA
290
QILEGGQQLA
300
HLKMSLSLEV
310
ATYRTLLEAE
320
NSRLQTPGRG
330
SQASLGFLDP
340
KLKPNFLGIP
350
EDQYLGSVLP
360
ALSPTSFPSP
370
LPNTLETPVT
380
AFLKTQEFLQ
390
ARTPTLASTP
400
IPPISEAPCP
410
PNAEVRAQEV
420
PLSLLQTQAP
430
EPLWAEATVP
440
SSSAILPELE
450
EPGGKQQGHF
460
PDDLTSLATT
470
LNPHHPTLEA
480
KDGESSGSRV
490
SSIFQEDEGQ
500
IWELVEKEAD
510
IEVKVENSSA
520
QKTQESGLDT
530
EETQDSQGPL
540
QKETLKALGE
550
EPLMSLKIQN
560
YETAGKENCN
570
SSTEGHLGTL
580
EGPEKEKQIP
590
LKSLEEKNVE
600
SEKTLENGVP
610
VLSELLGKED
620
TRTEDQELMS
630
PKGTLKRFSS
640
LGKESQEVVR
650
PSKEGNLESW
660
TAFKEESQHP
670
LGFPGAEDQM
680
LERLVEKEDQ
690
SFPRSPEEED
700
QEACRPLQKE
710
NQEPLGYEEA
720
EGQILERLIE
730
KESQESLRSP
740
EEEDQEAGRS
750
LQKGNQEPLG
760
YEEAEGQILE
770
RLIEKESQES
780
LRSAEEEDQE
790
ACRSLQKENQ
800
EPLGYEEAED
810
QILERLIEKE
820
SQESLRSPEE
830
EDQEAGRSLQ
840
KENQEPLGYE
850
EAEDQMLERL
860
IEKESQESLK
870
SPEENQRIGK
880
PLERENQKSL
890
RYLEENQETF
900
VPLESRNQRP
910
LRSLEVEEEE
920
QRIVKPLEKV
930
SQDSLGSLAE
940
ENVQPLRYLE
950
EDNCINKSLL
960
EDKTHKSLGS
970
LEDRNGDSII
980
IPQESETQVS
990
LRPPEEEDQR
1000
IVNHLEKESQ
1010
EFSRSSEEEE
1020
RVMERSLEGE
1030
NHESLSSVEK
1040
EDQMVESQLE
1050
KESQDSGKSL
1060
EDESQETFGP
1070
LEKENAESLR
1080
SLAGQDQEEQ
1090
KLEQETQQTL
1100
RAVGNEQMAV
1110
SPPEKVDPEL
1120
PKPLGNDQEI
1130
ARSLGKENQE
1140
SLVSLKEKGI
1150
ETVKSLETEI
1160
IEPLETAEED
1170
LERRKSIDTQ
1180
EPLWSTEVAR
1190
ETVEPPEDEP
1200
PGSLGSVDEN
1210
RETLTSLEKE
1220
SQELSSLGKW
1230
NVETRVEDSQ
1240
QCLQVEEGLQ
1250
EEQHQESLRE
1260
VKQELPSSGN
1270
QQRWEDVVEG
1280
KAVGQEAPLA
1290
TTGVGTEDKA
1300
ELHLRGQGGE
1310
EEAAAEGELL
1320
QDIVGEAWSL
1330
GSSEPKEQRV
1340
PAEALDNLEG
1350
GALEVPVAQS
1360
MPEVTERDED
1370
RAQAGEQDSI
1380
EVTLGLEAAR
1390
TGLELEQEVV
1400
GLEDPRHFAR
1410
EEAIPPSLGE
1420
ESVKAKIAQG
1430
LEGPGKEPKE
1440
AGALDSGILE
1450
LPKTSSEALE
1460
CQGHEESESM
1470
EGWEEEEASL
1480
ETSDHEGSDA
1490
PQPRPPETEE
1500
DEGAQAALTA
1510
PGPKLLEPCS
1520
PIPILTDAHE
1530
LQPQAEGIQE
1540
AGWQPEAGSE
1550
ALERVENEPE
1560
FGLGEIPEGL
1570
QDWEEGREES
1580
EADDLGETLP
1590
DSTPLGLYLR
1600
SPASPKWDLA
1610
GEQRLSPQGD
1620
AGKEDWGPAV
1630
PAAQGLSGPP
1640
EEEEEQGHGS
1650
DLSSEEFEDL
1660
GTEASLLPGV
1670
PKEVADHVGQ
1680
VPPVLQPACW
1690
DQGGESDGFA
1700
DEEESGEEGE
1710
EEDADEEGAE
1720
SGAQWWGSGA
1730
SGGGCKVQDI
1740
AQRGDPVQES
1750
VGVSGLWDDG
1760
LRGAAANVPA
1770
LEMVSQDSAE
1780
PSGSEESESA
1790
SLEGEEGQVT
1800
DHLDAPQEVT
1810
SMVPGVGDAF
1820
DIGGQSPNLD
1830
SEQVNGKMEN
1840
GLEQAEGQVV
1850
LDGDEDQELL
1860
LQGQEVGALK
1870
VPLVASPVHL
1880
GPSQPLKFTL
1890
SGVDGDSWSS
GED
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005882 | intermediate filament |
| Cellular Component | GO:0045111 | intermediate filament cytoskeleton |
| Molecular Function | GO:0031730 | CCR5 chemokine receptor binding |
| Molecular Function | GO:0019215 | intermediate filament binding |
| Biological Process | GO:0007420 | brain development |
| Biological Process | GO:0048858 | cell projection morphogenesis |
| Biological Process | GO:0031076 | embryonic camera-type eye development |
| Biological Process | GO:0000086 | G2/M transition of mitotic cell cycle |
| Biological Process | GO:0043086 | negative regulation of catalytic activity |
| Biological Process | GO:0043524 | negative regulation of neuron apoptotic process |
| Biological Process | GO:0007399 | nervous system development |
| Biological Process | GO:0030182 | neuron differentiation |
| Biological Process | GO:0030844 | positive regulation of intermediate filament depolymerization |
| Biological Process | GO:2000179 | positive regulation of neural precursor cell proliferation |
| Biological Process | GO:0010212 | response to ionizing radiation |
| Biological Process | GO:0031667 | response to nutrient levels |
| Biological Process | GO:0009410 | response to xenobiotic stimulus |
| Biological Process | GO:0072089 | stem cell proliferation |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.