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Overview

Uniprot IDP21263
Protein NameNestin
Gene NameNes
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
1126 EIARSLGKENQESLV
1136 QESLVSLKEKGIETV
1138 SLVSLKEKGIETVKS
120 RRALEAEKNARGWLS
1219 QELSSLGKWNVETRV
1416 GEESVKAKIAQGLEG
1426 QGLEGPGKEPKEAGA
1596 LRSPASPKWDLAGEQ
547 EEPLMSLKIQNYETA
582 KEKQIPLKSLEEKNV
587 PLKSLEEKNVESEKT
622 DQELMSPKGTLKRFS
633 KRFSSLGKESQEVVR
643 QEVVRPSKEGNLESW
721 ILERLIEKESQESLR
853 MLERLIEKESQESLK
878 PLERENQKSLRYLEE
953 NKSLLEDKTHKSLGS
956 LLEDKTHKSLGSLED

Function

Required for brain and eye development (By similarity). Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells

Protein Sequence

10 MEGCVGEESF 20 QMWELNRRLE 30 AYLTRVKTLE 40 EQNQLLSAEL 50 GGLRAQSGDT 60 SWRARADDEL 70 ASLRILVDQR 80 WREKLEAEVQ 90 RDNLAEELES 100 VAGRCQQVRL 110 ARERTVQEAA 120 CSRRALEAEK 130 NARGWLSTQA 140 AELERELEAL 150 RAAHEEERAH 160 LNAQAACAPR 170 RPPAPPHGSP 180 VRAPEVEDLA 190 RRLGEVWRGA 200 VRDYQERVAH 210 MESSLGQARE 220 RLSQAVRGAR 230 ECRLEVQQLQ 240 ADRDSLQERR 250 EALEQRLEGR 260 WQDRLQATDK 270 FQLAVEALEQ 280 EKQGLQSQIA 290 QILEGGQQLA 300 HLKMSLSLEV 310 ATYRTLLEAE 320 NSRLQTPGRG 330 SQASLGFLDP 340 KLKPNFLGIP 350 EDQYLGSVLP 360 ALSPTSFPSP 370 LPNTLETPVT 380 AFLKTQEFLQ 390 ARTPTLASTP 400 IPPISEAPCP 410 PNAEVRAQEV 420 PLSLLQTQAP 430 EPLWAEATVP 440 SSSAILPELE 450 EPGGKQQGHF 460 PDDLTSLATT 470 LNPHHPTLEA 480 KDGESSGSRV 490 SSIFQEDEGQ 500 IWELVEKEAD 510 IEVKVENSSA 520 QKTQESGLDT 530 EETQDSQGPL 540 QKETLKALGE 550 EPLMSLKIQN 560 YETAGKENCN 570 SSTEGHLGTL 580 EGPEKEKQIP 590 LKSLEEKNVE 600 SEKTLENGVP 610 VLSELLGKED 620 TRTEDQELMS 630 PKGTLKRFSS 640 LGKESQEVVR 650 PSKEGNLESW 660 TAFKEESQHP 670 LGFPGAEDQM 680 LERLVEKEDQ 690 SFPRSPEEED 700 QEACRPLQKE 710 NQEPLGYEEA 720 EGQILERLIE 730 KESQESLRSP 740 EEEDQEAGRS 750 LQKGNQEPLG 760 YEEAEGQILE 770 RLIEKESQES 780 LRSAEEEDQE 790 ACRSLQKENQ 800 EPLGYEEAED 810 QILERLIEKE 820 SQESLRSPEE 830 EDQEAGRSLQ 840 KENQEPLGYE 850 EAEDQMLERL 860 IEKESQESLK 870 SPEENQRIGK 880 PLERENQKSL 890 RYLEENQETF 900 VPLESRNQRP 910 LRSLEVEEEE 920 QRIVKPLEKV 930 SQDSLGSLAE 940 ENVQPLRYLE 950 EDNCINKSLL 960 EDKTHKSLGS 970 LEDRNGDSII 980 IPQESETQVS 990 LRPPEEEDQR 1000 IVNHLEKESQ 1010 EFSRSSEEEE 1020 RVMERSLEGE 1030 NHESLSSVEK 1040 EDQMVESQLE 1050 KESQDSGKSL 1060 EDESQETFGP 1070 LEKENAESLR 1080 SLAGQDQEEQ 1090 KLEQETQQTL 1100 RAVGNEQMAV 1110 SPPEKVDPEL 1120 PKPLGNDQEI 1130 ARSLGKENQE 1140 SLVSLKEKGI 1150 ETVKSLETEI 1160 IEPLETAEED 1170 LERRKSIDTQ 1180 EPLWSTEVAR 1190 ETVEPPEDEP 1200 PGSLGSVDEN 1210 RETLTSLEKE 1220 SQELSSLGKW 1230 NVETRVEDSQ 1240 QCLQVEEGLQ 1250 EEQHQESLRE 1260 VKQELPSSGN 1270 QQRWEDVVEG 1280 KAVGQEAPLA 1290 TTGVGTEDKA 1300 ELHLRGQGGE 1310 EEAAAEGELL 1320 QDIVGEAWSL 1330 GSSEPKEQRV 1340 PAEALDNLEG 1350 GALEVPVAQS 1360 MPEVTERDED 1370 RAQAGEQDSI 1380 EVTLGLEAAR 1390 TGLELEQEVV 1400 GLEDPRHFAR 1410 EEAIPPSLGE 1420 ESVKAKIAQG 1430 LEGPGKEPKE 1440 AGALDSGILE 1450 LPKTSSEALE 1460 CQGHEESESM 1470 EGWEEEEASL 1480 ETSDHEGSDA 1490 PQPRPPETEE 1500 DEGAQAALTA 1510 PGPKLLEPCS 1520 PIPILTDAHE 1530 LQPQAEGIQE 1540 AGWQPEAGSE 1550 ALERVENEPE 1560 FGLGEIPEGL 1570 QDWEEGREES 1580 EADDLGETLP 1590 DSTPLGLYLR 1600 SPASPKWDLA 1610 GEQRLSPQGD 1620 AGKEDWGPAV 1630 PAAQGLSGPP 1640 EEEEEQGHGS 1650 DLSSEEFEDL 1660 GTEASLLPGV 1670 PKEVADHVGQ 1680 VPPVLQPACW 1690 DQGGESDGFA 1700 DEEESGEEGE 1710 EEDADEEGAE 1720 SGAQWWGSGA 1730 SGGGCKVQDI 1740 AQRGDPVQES 1750 VGVSGLWDDG 1760 LRGAAANVPA 1770 LEMVSQDSAE 1780 PSGSEESESA 1790 SLEGEEGQVT 1800 DHLDAPQEVT 1810 SMVPGVGDAF 1820 DIGGQSPNLD 1830 SEQVNGKMEN 1840 GLEQAEGQVV 1850 LDGDEDQELL 1860 LQGQEVGALK 1870 VPLVASPVHL 1880 GPSQPLKFTL 1890 SGVDGDSWSS GED

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005882 intermediate filament
Cellular Component GO:0045111 intermediate filament cytoskeleton
Molecular Function GO:0031730 CCR5 chemokine receptor binding
Molecular Function GO:0019215 intermediate filament binding
Biological Process GO:0007420 brain development
Biological Process GO:0048858 cell projection morphogenesis
Biological Process GO:0031076 embryonic camera-type eye development
Biological Process GO:0000086 G2/M transition of mitotic cell cycle
Biological Process GO:0043086 negative regulation of catalytic activity
Biological Process GO:0043524 negative regulation of neuron apoptotic process
Biological Process GO:0007399 nervous system development
Biological Process GO:0030182 neuron differentiation
Biological Process GO:0030844 positive regulation of intermediate filament depolymerization
Biological Process GO:2000179 positive regulation of neural precursor cell proliferation
Biological Process GO:0010212 response to ionizing radiation
Biological Process GO:0031667 response to nutrient levels
Biological Process GO:0009410 response to xenobiotic stimulus
Biological Process GO:0072089 stem cell proliferation

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.