Search Results

Overview

Uniprot IDP21266
Protein NameGlutathione S-transferase Mu 3
Gene NameGSTM3
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
126 CYSSDHEKLKPQYLE
128 SSDHEKLKPQYLEEL
186 LDEFPNLKAFMCRFE
209 LQSDQFCKMPINNKM
35 TDTSYEEKRYTCGEA
54 RSQWLDVKFKLDLDF
73 YLLDGKNKITQSNAI
87 ILRYIARKHNMCGET
98 CGETEEEKIRVDIIE

Function

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. May govern uptake and detoxification of both endogenous compounds and xenobiotics at the testis and brain blood barriers

Protein Sequence

10 MSCESSMVLG 20 YWDIRGLAHA 30 IRLLLEFTDT 40 SYEEKRYTCG 50 EAPDYDRSQW 60 LDVKFKLDLD 70 FPNLPYLLDG 80 KNKITQSNAI 90 LRYIARKHNM 100 CGETEEEKIR 110 VDIIENQVMD 120 FRTQLIRLCY 130 SSDHEKLKPQ 140 YLEELPGQLK 150 QFSMFLGKFS 160 WFAGEKLTFV 170 DFLTYDILDQ 180 NRIFDPKCLD 190 EFPNLKAFMC 200 RFEALEKIAA 210 YLQSDQFCKM 220 PINNKMAQWG NKPVC

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005634 nucleus
Cellular Component GO:0035686 sperm fibrous sheath
Molecular Function GO:0019899 enzyme binding
Molecular Function GO:0043295 glutathione binding
Molecular Function GO:0004364 glutathione transferase activity
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0042803 protein homodimerization activity
Biological Process GO:0070458 cellular detoxification of nitrogen compound
Biological Process GO:0008065 establishment of blood-nerve barrier
Biological Process GO:0006749 glutathione metabolic process
Biological Process GO:0018916 nitrobenzene metabolic process
Biological Process GO:0043627 response to estrogen
Biological Process GO:0042178 xenobiotic catabolic process

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[4] Yan M, Tu H, Tang S, Gai Z, Shi Q et al.. Lactylated Proteomic Analysis Reveals Functional Implications of Lysine Lactylation In Asthenozoospermia.. Mol Cell Proteomics 24(12):101439. 2025 Dec. PMID: 41192556.