Search Results

Overview

Uniprot IDP21272
Protein NameCCAAT/enhancer-binding protein beta
Gene NameCebpb
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
102 DYGAKPSKKPSDYGY
212 GPPAAPAKAKAKKAV
221 KAKKAVDKLSDEYKM

Function

Important transcription factor regulating the expression of genes involved in immune and inflammatory responses (PubMed:8336793). Also plays a significant role in adipogenesis, as well as in the gluconeogenic pathway, liver regeneration, and hematopoiesis (PubMed:10635333). The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Its functional capacity is governed by protein interactions and post-translational protein modifications. During early embryogenesis, plays essential and redundant roles with CEBPA (By similarity). Has a promitotic effect on many cell types such as hepatocytes and adipocytes but has an antiproliferative effect on T-cells by repressing MYC expression, facilitating differentiation along the T-helper 2 lineage (PubMed:10635333). Binds to regulatory regions of several acute-phase and cytokines genes and plays a role in the regulation of acute-phase reaction and inflammation. Also plays a role in intracellular bacteria killing (By similarity). During adipogenesis, is rapidly expressed and, after activation by phosphorylation, induces CEBPA and PPARG, which turn on the series of adipocyte genes that give rise to the adipocyte phenotype. The delayed transactivation of the CEBPA and PPARG genes by CEBPB appears necessary to allow mitotic clonal expansion and thereby progression of terminal differentiation (By similarity). Essential for female reproduction because of a critical role in ovarian follicle development (By similarity). Restricts osteoclastogenesis: together with NFE2L1; represses expression of DSPP during odontoblast differentiation (PubMed:15308669)

Protein Sequence

10 MHRLLAWDAA 20 CLPPPPAAFR 30 PMEVANFYYE 40 PDCLAYGAKA 50 ARAAPRAPAA 60 EPAIGEHERA 70 IDFSPYLEPL 80 APAAADFAAP 90 APAHHDFLSD 100 LFADDYGAKP 110 SKKPSDYGYV 120 SLGRAGAKAA 130 PPACFPPPPP 140 AALKAEPGFE 150 PADCKRADDA 160 PAMAAGFPFA 170 LRAYLGYQAT 180 PSGSSGSLST 190 SSSSSPPGTP 200 SPADAKAAPA 210 ACFAGPPAAP 220 AKAKAKKAVD 230 KLSDEYKMRR 240 ERNNIAVRKS 250 RDKAKMRNLE 260 TQHKVLELTA 270 ENERLQKKVE 280 QLSRELSTLR 290 NLFKQLPEPL LASAGHC

Gene Ontology

Classification GO ID Description
Cellular Component GO:1990647 C/EBP complex
Biological Process GO:0035711 T-helper 1 cell activation
Cellular Component GO:0036488 CHOP-C/EBP complex
Cellular Component GO:0000785 chromatin
Cellular Component GO:0000779 condensed chromosome, centromeric region
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0016363 nuclear matrix
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0090575 RNA polymerase II transcription regulator complex
Molecular Function GO:0003682 chromatin binding
Molecular Function GO:0031490 chromatin DNA binding
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
Molecular Function GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Function GO:0140297 DNA-binding transcription factor binding
Molecular Function GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
Molecular Function GO:0035035 histone acetyltransferase binding
Molecular Function GO:0042826 histone deacetylase binding
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0019900 kinase binding
Molecular Function GO:0035259 nuclear glucocorticoid receptor binding
Molecular Function GO:0046982 protein heterodimerization activity
Molecular Function GO:0042803 protein homodimerization activity
Molecular Function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular Function GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding
Molecular Function GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
Molecular Function GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding
Molecular Function GO:0043565 sequence-specific DNA binding
Molecular Function GO:1990837 sequence-specific double-stranded DNA binding
Molecular Function GO:0000976 transcription cis-regulatory region binding
Molecular Function GO:0044389 ubiquitin-like protein ligase binding
Biological Process GO:0050873 brown fat cell differentiation
Biological Process GO:0071230 cellular response to amino acid stimulus
Biological Process GO:0071347 cellular response to interleukin-1
Biological Process GO:0071222 cellular response to lipopolysaccharide
Biological Process GO:0042742 defense response to bacterium
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0001892 embryonic placenta development
Biological Process GO:0045444 fat cell differentiation
Biological Process GO:0002432 granuloma formation
Biological Process GO:0072574 hepatocyte proliferation
Biological Process GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
Biological Process GO:0001889 liver development
Biological Process GO:0097421 liver regeneration
Biological Process GO:0060644 mammary gland epithelial cell differentiation
Biological Process GO:0033598 mammary gland epithelial cell proliferation
Biological Process GO:0007613 memory
Biological Process GO:0045892 negative regulation of DNA-templated transcription
Biological Process GO:0043524 negative regulation of neuron apoptotic process
Biological Process GO:0042130 negative regulation of T cell proliferation
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0030182 neuron differentiation
Biological Process GO:0001541 ovarian follicle development
Biological Process GO:0070169 positive regulation of biomineral tissue development
Biological Process GO:0120162 positive regulation of cold-induced thermogenesis
Biological Process GO:0045893 positive regulation of DNA-templated transcription
Biological Process GO:0045600 positive regulation of fat cell differentiation
Biological Process GO:0010628 positive regulation of gene expression
Biological Process GO:0050729 positive regulation of inflammatory response
Biological Process GO:0032753 positive regulation of interleukin-4 production
Biological Process GO:0045669 positive regulation of osteoblast differentiation
Biological Process GO:2000120 positive regulation of sodium-dependent phosphate transport
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0045595 regulation of cell differentiation
Biological Process GO:2001198 regulation of dendritic cell differentiation
Biological Process GO:0006355 regulation of DNA-templated transcription
Biological Process GO:0032675 regulation of interleukin-6 production
Biological Process GO:1901329 regulation of odontoblast differentiation
Biological Process GO:0045670 regulation of osteoclast differentiation
Biological Process GO:0006357 regulation of transcription by RNA polymerase II
Biological Process GO:0034976 response to endoplasmic reticulum stress
Biological Process GO:0032496 response to lipopolysaccharide

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.