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Overview

Uniprot ID	P21281
Protein Name	V-type proton ATPase subunit B, brain isoform
Gene Name	ATP6V1B2
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
108	GTSGIDAKKTSCEFT
109	TSGIDAKKTSCEFTG
188	NSIARGQKIPIFSAA
48	SQPRLTYKTVSGVNG
81	LTLPDGTKRSGQVLE

Function

Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:33065002). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it promotes acidification of the extracellular environment (PubMed:32001091). The V-ATPase complex also acts as an activator for mTORC1 on lysosomal membrane by promoting the guanine nucleotide exchange factor (GEF) of the Ragulator complex, thereby enabling mTORC1 recruitment (PubMed:22053050). In renal intercalated cells, can partially compensate the lack of ATP6V1B1 and mediate secretion of protons (H+) into the urine under base-line conditions but not in conditions of acid load (By similarity)

Protein Sequence

10 MALRAMRGIV 20 NGAAPELPVP 30 TGGPAVGARE 40 QALAVSRNYL 50 SQPRLTYKTV 60 SGVNGPLVIL 70 DHVKFPRYAE 80 IVHLTLPDGT 90 KRSGQVLEVS 100 GSKAVVQVFE 110 GTSGIDAKKT 120 SCEFTGDILR 130 TPVSEDMLGR 140 VFNGSGKPID 150 RGPVVLAEDF 160 LDIMGQPINP 170 QCRIYPEEMI 180 QTGISAIDGM 190 NSIARGQKIP 200 IFSAAGLPHN 210 EIAAQICRQA 220 GLVKKSKDVV 230 DYSEENFAIV 240 FAAMGVNMET 250 ARFFKSDFEE 260 NGSMDNVCLF 270 LNLANDPTIE 280 RIITPRLALT 290 TAEFLAYQCE 300 KHVLVILTDM 310 SSYAEALREV 320 SAAREEVPGR 330 RGFPGYMYTD 340 LATIYERAGR 350 VEGRNGSITQ 360 IPILTMPNDD 370 ITHPIPDLTG 380 YITEGQIYVD 390 RQLHNRQIYP 400 PINVLPSLSR 410 LMKSAIGEGM 420 TRKDHADVSN 430 QLYACYAIGK 440 DVQAMKAVVG 450 EEALTSDDLL 460 YLEFLQKFER 470 NFIAQGPYEN 480 RTVFETLDIG 490 WQLLRIFPKE 500 MLKRIPQSTL 510 SEFYPRDSAK H

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0016324	apical plasma membrane
Cellular Component	GO:0070062	extracellular exosome
Cellular Component	GO:0098850	extrinsic component of synaptic vesicle membrane
Cellular Component	GO:0005765	lysosomal membrane
Cellular Component	GO:0042470	melanosome
Cellular Component	GO:0005902	microvillus
Cellular Component	GO:0005886	plasma membrane
Cellular Component	GO:0001726	ruffle
Cellular Component	GO:0000221	vacuolar proton-transporting V-type ATPase, V1 domain
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0015078	proton transmembrane transporter activity
Molecular Function	GO:0046961	proton-transporting ATPase activity, rotational mechanism
Biological Process	GO:0046034	ATP metabolic process
Biological Process	GO:1902600	proton transmembrane transport
Biological Process	GO:0016241	regulation of macroautophagy
Biological Process	GO:0097401	synaptic vesicle lumen acidification
Biological Process	GO:0007035	vacuolar acidification
Cellular Component	GO:0030665	clathrin-coated vesicle membrane
Cellular Component	GO:0005829	cytosol

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.