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Overview

Uniprot IDP21283
Protein NameV-type proton ATPase subunit C 1
Gene NameATP6V1C1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
147 ASAYNNLKGNLQNLE
232 CNVTLFRKAVDDFRH
240 AVDDFRHKARENKFI
245 RHKARENKFIVRDFQ

Function

Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:33065002). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it promotes acidification of the extracellular environment (By similarity). The V-ATPase complex also acts as an activator for mTORC1 on lysosomal membrane by promoting the guanine nucleotide exchange factor (GEF) of the Ragulator complex, thereby enabling mTORC1 recruitment (PubMed:22053050). Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity (By similarity)

Protein Sequence

10 MTEFWLISAP 20 GEKTCQQTWE 30 KLHAATSKNN 40 NLAVTSKFNI 50 PDLKVGTLDV 60 LVGLSDELAK 70 LDAFVEGVVK 80 KVAQYMADVL 90 EDSKDKVQEN 100 LLANGVDLVT 110 YITRFQWDMA 120 KYPIKQSLKN 130 ISEIIAKGVT 140 QIDNDLKSRA 150 SAYNNLKGNL 160 QNLERKNAGS 170 LLTRSLAEIV 180 KKDDFVLDSE 190 YLVTLLVVVP 200 KLNHNDWIKQ 210 YETLAEMVVP 220 RSSNVLSEDQ 230 DSYLCNVTLF 240 RKAVDDFRHK 250 ARENKFIVRD 260 FQYNEEEMKA 270 DKEEMNRLST 280 DKKKQFGPLV 290 RWLKVNFSEA 300 FIAWIHVKAL 310 RVFVESVLRY 320 GLPVNFQAML 330 LQPNKKTLKK 340 LREVLHELYK 350 HLDSSAAAII 360 DAPMDIPGLN 370 LSQQEYYPYV 380 YYKIDCNLLE FK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0045177 apical part of cell
Cellular Component GO:0030665 clathrin-coated vesicle membrane
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0098850 extrinsic component of synaptic vesicle membrane
Cellular Component GO:0005765 lysosomal membrane
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0016469 proton-transporting two-sector ATPase complex
Cellular Component GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain
Molecular Function GO:0046961 proton-transporting ATPase activity, rotational mechanism
Biological Process GO:1902600 proton transmembrane transport
Biological Process GO:0016241 regulation of macroautophagy
Biological Process GO:0097401 synaptic vesicle lumen acidification

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[3] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.

[4] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.