Search Results

Overview

Uniprot IDP21291
Protein NameCysteine and glycine-rich protein 1
Gene NameCSRP1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
108 TTNPNASKFAQKIGG
112 NASKFAQKIGGSERC
137 EKVIGAGKSWHKACF
161 ESTTLADKDGEIYCK
168 KDGEIYCKGCYAKNF
173 YCKGCYAKNFGPKGF
178 YAKNFGPKGFGFGQG
41 CFLCMVCKKNLDSTT
42 FLCMVCKKNLDSTTV
59 HGEEIYCKSCYGKKY
69 YGKKYGPKGYGYGQG
84 AGTLSTDKGESLGIK
91 KGESLGIKHEEAPGH

Function

Could play a role in neuronal development

Protein Sequence

10 MPNWGGGKKC 20 GVCQKTVYFA 30 EEVQCEGNSF 40 HKSCFLCMVC 50 KKNLDSTTVA 60 VHGEEIYCKS 70 CYGKKYGPKG 80 YGYGQGAGTL 90 STDKGESLGI 100 KHEEAPGHRP 110 TTNPNASKFA 120 QKIGGSERCP 130 RCSQAVYAAE 140 KVIGAGKSWH 150 KACFRCAKCG 160 KGLESTTLAD 170 KDGEIYCKGC 180 YAKNFGPKGF 190 GFGQGAGALV HSE

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005925 focal adhesion
Cellular Component GO:0005634 nucleus
Cellular Component GO:0030018 Z disc
Molecular Function GO:0042805 actinin binding
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0008307 structural constituent of muscle
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0060537 muscle tissue development
Biological Process GO:0070527 platelet aggregation
Biological Process GO:0045214 sarcomere organization

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[4] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[5] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.

[6] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.

[7] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[8] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[9] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[10] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[11] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[12] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.