Search Results
Overview
| Uniprot ID | P21300 |
|---|---|
| Protein Name | Aldo-keto reductase family 1 member B7 |
| Gene Name | Akr1b7 |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 91 | FEKSLVKKAFQNTLS |
Function
Reduces a broad range of aliphatic and aromatic aldehydes to the corresponding alcohols. Reduces prostaglandins (PubMed:19010934). May play a role in the metabolism of xenobiotic aromatic aldehydes (By similarity)
Protein Sequence
10
MATFVELSTK
20
AKMPLVGLGT
30
WKSSPGQVKE
40
AVKAAIDAGY
50
RHIDCAYVYH
60
NENEVGEAIQ
70
EKIKENAVKR
80
EDLFIVSKLW
90
ATFFEKSLVK
100
KAFQNTLSDL
110
KLDYLDLYLV
120
HWPQGFQAGN
130
ALLPKDNKGK
140
VLLSKSTFLD
150
AWEAMEELVD
160
QGLVKALGIS
170
NFNHFQIERL
180
LNKPGLKHKP
190
VTNQIESHPY
200
LTQEKLIQYC
210
QSKGIAVTAY
220
SPLGSPDRPY
230
AKPEDPVVME
240
IPKIKEIAAK
250
HKKTVAQVLI
260
RFHVQRNVVV
270
IPKSVTPSRI
280
QENLQVFDFQ
290
LSEEDMAAIL
300
SFNRNWRACD
310
LLDARTEEDY
PFHEEY
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0005764 | lysosome |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0008106 | alcohol dehydrogenase (NADP+) activity |
| Molecular Function | GO:0004032 | aldose reductase (NADPH) activity |
| Molecular Function | GO:0052650 | all-trans-retinol dehydrogenase (NADP+) activity |
| Molecular Function | GO:0004303 | estradiol 17-beta-dehydrogenase [NAD(P)+] activity |
| Molecular Function | GO:0045550 | geranylgeranyl reductase activity |
| Molecular Function | GO:0047718 | indanol dehydrogenase activity |
| Molecular Function | GO:0016616 | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| Molecular Function | GO:0036130 | prostaglandin H2 endoperoxidase reductase activity |
| Molecular Function | GO:0001758 | retinal dehydrogenase (NAD+) activity |
| Biological Process | GO:0006629 | lipid metabolic process |
Reference
[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.
[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.