Overview
| Uniprot ID | P21397 |
|---|
| Protein Name | Amine oxidase [flavin-containing] A |
|---|
| Gene Name | MAOA |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 151 |
WEAQHADKWDKMTMK |
| 218 |
TNGGQERKFVGGSGQ |
| 267 |
NHEHYECKYVINAIP |
| 465 |
EVLNGLGKVTEKDIW |
| 469 |
GLGKVTEKDIWVQEP |
| 82 |
NRILRLSKELGIETY |
| 90 |
ELGIETYKVNVSERL |
Function
Catalyzes the oxidative deamination of primary and some secondary amine such as neurotransmitters, with concomitant reduction of oxygen to hydrogen peroxide and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues (PubMed:18391214, PubMed:20493079, PubMed:24169519, PubMed:8316221). Preferentially oxidizes serotonin (PubMed:20493079, PubMed:24169519). Also catalyzes the oxidative deamination of kynuramine to 3-(2-aminophenyl)-3-oxopropanal that can spontaneously condense to 4-hydroxyquinoline (By similarity)
Protein Sequence
10
MENQEKASIA
20
GHMFDVVVIG
30
GGISGLSAAK
40
LLTEYGVSVL
50
VLEARDRVGG
60
RTYTIRNEHV
70
DYVDVGGAYV
80
GPTQNRILRL
90
SKELGIETYK
100
VNVSERLVQY
110
VKGKTYPFRG
120
AFPPVWNPIA
130
YLDYNNLWRT
140
IDNMGKEIPT
150
DAPWEAQHAD
160
KWDKMTMKEL
170
IDKICWTKTA
180
RRFAYLFVNI
190
NVTSEPHEVS
200
ALWFLWYVKQ
210
CGGTTRIFSV
220
TNGGQERKFV
230
GGSGQVSERI
240
MDLLGDQVKL
250
NHPVTHVDQS
260
SDNIIIETLN
270
HEHYECKYVI
280
NAIPPTLTAK
290
IHFRPELPAE
300
RNQLIQRLPM
310
GAVIKCMMYY
320
KEAFWKKKDY
330
CGCMIIEDED
340
APISITLDDT
350
KPDGSLPAIM
360
GFILARKADR
370
LAKLHKEIRK
380
KKICELYAKV
390
LGSQEALHPV
400
HYEEKNWCEE
410
QYSGGCYTAY
420
FPPGIMTQYG
430
RVIRQPVGRI
440
FFAGTETATK
450
WSGYMEGAVE
460
AGERAAREVL
470
NGLGKVTEKD
480
IWVQEPESKD
490
VPAVEITHTF
500
WERNLPSVSG
510
LLKIIGFSTS
520
VTALGFVLYK
YKLLPRS
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005741 |
mitochondrial outer membrane |
| Cellular Component |
GO:0005739 |
mitochondrion |
| Molecular Function |
GO:0097621 |
monoamine oxidase activity |
| Molecular Function |
GO:0008131 |
primary methylamine oxidase activity |
| Biological Process |
GO:0006576 |
biogenic amine metabolic process |
| Biological Process |
GO:0042420 |
dopamine catabolic process |
| Biological Process |
GO:0019607 |
phenylethylamine catabolic process |
| Biological Process |
GO:0042429 |
serotonin catabolic process |
| Biological Process |
GO:0042428 |
serotonin metabolic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.