Search Results

Overview

Uniprot IDP21549
Protein NameAlanine--glyoxylate aminotransferase
Gene NameAGXT
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
12 KLLVTPPKALLKPLS
128 ARVHPMTKDPGGHYT
16 TPPKALLKPLSIPNQ
225 SLISFSDKAKKKMYS
234 KKKMYSRKTKPFSFY
312 LGLQLFVKDPALRLP
389 AALQHCPKKKL****
5 ***MASHKLLVTPPK

Function

Peroxisomal aminotransferase that catalyzes the transamination of glyoxylate to glycine and contributes to the glyoxylate detoxification (PubMed:10960483, PubMed:12777626, PubMed:23229545, PubMed:24055001, PubMed:26149463). Also catalyzes the transamination between L-serine and pyruvate and contributes to gluconeogenesis from the L-serine metabolism (PubMed:10347152)

Protein Sequence

10 MASHKLLVTP 20 PKALLKPLSI 30 PNQLLLGPGP 40 SNLPPRIMAA 50 GGLQMIGSMS 60 KDMYQIMDEI 70 KEGIQYVFQT 80 RNPLTLVISG 90 SGHCALEAAL 100 VNVLEPGDSF 110 LVGANGIWGQ 120 RAVDIGERIG 130 ARVHPMTKDP 140 GGHYTLQEVE 150 EGLAQHKPVL 160 LFLTHGESST 170 GVLQPLDGFG 180 ELCHRYKCLL 190 LVDSVASLGG 200 TPLYMDRQGI 210 DILYSGSQKA 220 LNAPPGTSLI 230 SFSDKAKKKM 240 YSRKTKPFSF 250 YLDIKWLANF 260 WGCDDQPRMY 270 HHTIPVISLY 280 SLRESLALIA 290 EQGLENSWRQ 300 HREAAAYLHG 310 RLQALGLQLF 320 VKDPALRLPT 330 VTTVAVPAGY 340 DWRDIVSYVI 350 DHFDIEIMGG 360 LGPSTGKVLR 370 IGLLGCNATR 380 ENVDRVTEAL 390 RAALQHCPKK KL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005782 peroxisomal matrix
Cellular Component GO:0005777 peroxisome
Molecular Function GO:0008453 alanine-glyoxylate transaminase activity
Molecular Function GO:0016597 amino acid binding
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0004760 L-serine-pyruvate transaminase activity
Molecular Function GO:0042803 protein homodimerization activity
Molecular Function GO:0030170 pyridoxal phosphate binding
Molecular Function GO:0008483 transaminase activity
Biological Process GO:0019265 glycine biosynthetic process, by transamination of glyoxylate
Biological Process GO:0009436 glyoxylate catabolic process
Biological Process GO:0046487 glyoxylate metabolic process
Biological Process GO:0042853 L-alanine catabolic process
Biological Process GO:0019448 L-cysteine catabolic process
Biological Process GO:0006563 L-serine metabolic process

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.