Search Results
Overview
| Uniprot ID | P21571 |
|---|---|
| Protein Name | ATP synthase peripheral stalk subunit F6, mitochondrial |
| Gene Name | Atp5pf |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 79 | DRELFKLKQMYGKGE |
| 84 | KLKQMYGKGEMDKFP |
Function
Subunit F6, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). Part of the complex F(0) domain (By similarity). Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements (By similarity)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0009986 | cell surface |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0005743 | mitochondrial inner membrane |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0045259 | proton-transporting ATP synthase complex |
| Molecular Function | GO:0044877 | protein-containing complex binding |
| Molecular Function | GO:0015078 | proton transmembrane transporter activity |
| Biological Process | GO:1900139 | negative regulation of arachidonate secretion |
| Biological Process | GO:0032307 | negative regulation of prostaglandin secretion |
| Biological Process | GO:0045777 | positive regulation of blood pressure |
| Biological Process | GO:0010460 | positive regulation of heart rate |
| Biological Process | GO:0042776 | proton motive force-driven mitochondrial ATP synthesis |
| Biological Process | GO:0014850 | response to muscle activity |
Reference
[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.
[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.