Search Results
Overview
| Uniprot ID | P21575 |
|---|---|
| Protein Name | Dynamin-1 |
| Gene Name | Dnm1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 113 | DRVTGTNKGISPVPI |
| 191 | SDALKIAKEVDPQGQ |
| 240 | GVVNRSQKDIDGKKD |
| 246 | QKDIDGKKDITAALA |
| 257 | AALAAERKFFLSHPS |
| 299 | TLPGLRNKLQSQLLS |
| 382 | VKMEFDEKELRREIS |
| 393 | REISYAIKNIHGIRT |
| 510 | SNQMNKKKTSGNQDE |
| 535 | INNIGIMKGGSKEYW |
| 562 | DDEEKEKKYMLSVDN |
| 571 | MLSVDNLKLRDVEKG |
| 577 | LKLRDVEKGFMSSKH |
| 598 | TEQRNVYKDYRQLEL |
| 90 | FLHCKGKKFTDFEEV |
Function
Catalyzes the hydrolysis of GTP and utilizes this energy to mediate vesicle scission and participates in many forms of endocytosis, such as clathrin-mediated endocytosis or synaptic vesicle endocytosis as well as rapid endocytosis (RE). Associates to the membrane, through lipid binding, and self-assembles into rings and stacks of interconnected rings through oligomerization to form a helical polymer around the vesicle membrane leading to constriction of invaginated coated pits around their necks. Self-assembly of the helical polymer induces membrane tubules narrowing until the polymer reaches a length sufficient to trigger GTP hydrolysis. Depending on the curvature imposed on the tubules, membrane detachment from the helical polymer upon GTP hydrolysis can cause spontaneous hemifission followed by complete fission. May play a role in regulating early stages of clathrin-mediated endocytosis in non-neuronal cells through its activation by dephosphorylation via the signaling downstream of EGFR (By similarity). Controls vesicle size at a step before fission, during formation of membrane pits, at hippocampal synapses. Controls plastic adaptation of the synaptic vesicle recycling machinery to high levels of activity (By similarity). Mediates rapid endocytosis (RE), a Ca(2+)-dependent and clathrin- and K(+)-independent process in chromaffin cells. Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP (By similarity). Through its interaction with DNAJC6, acts during the early steps of clathrin-coated vesicle (CCV) formation (By similarity)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0042583 | chromaffin granule |
| Cellular Component | GO:0005905 | clathrin-coated pit |
| Cellular Component | GO:0030136 | clathrin-coated vesicle |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0030139 | endocytic vesicle |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0005794 | Golgi apparatus |
| Cellular Component | GO:0030117 | membrane coat |
| Cellular Component | GO:0005874 | microtubule |
| Cellular Component | GO:0001917 | photoreceptor inner segment |
| Cellular Component | GO:0098684 | photoreceptor ribbon synapse |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0098793 | presynapse |
| Cellular Component | GO:0098835 | presynaptic endocytic zone membrane |
| Cellular Component | GO:0032991 | protein-containing complex |
| Cellular Component | GO:0045202 | synapse |
| Cellular Component | GO:0008021 | synaptic vesicle |
| Cellular Component | GO:0043196 | varicosity |
| Molecular Function | GO:0031749 | D2 dopamine receptor binding |
| Molecular Function | GO:0019003 | GDP binding |
| Molecular Function | GO:0005525 | GTP binding |
| Molecular Function | GO:0003924 | GTPase activity |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0008017 | microtubule binding |
| Molecular Function | GO:0050998 | nitric-oxide synthase binding |
| Molecular Function | GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding |
| Molecular Function | GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0019901 | protein kinase binding |
| Molecular Function | GO:0120283 | protein serine/threonine kinase binding |
| Molecular Function | GO:0044877 | protein-containing complex binding |
| Molecular Function | GO:0017124 | SH3 domain binding |
| Biological Process | GO:0099049 | clathrin coat assembly involved in endocytosis |
| Biological Process | GO:0006897 | endocytosis |
| Biological Process | GO:0007032 | endosome organization |
| Biological Process | GO:0002031 | G protein-coupled receptor internalization |
| Biological Process | GO:0050804 | modulation of chemical synaptic transmission |
| Biological Process | GO:1900244 | positive regulation of synaptic vesicle endocytosis |
| Biological Process | GO:1903423 | positive regulation of synaptic vesicle recycling |
| Biological Process | GO:0051260 | protein homooligomerization |
| Biological Process | GO:0051289 | protein homotetramerization |
| Biological Process | GO:0031623 | receptor internalization |
| Biological Process | GO:0006898 | receptor-mediated endocytosis |
| Biological Process | GO:1900242 | regulation of synaptic vesicle endocytosis |
| Biological Process | GO:0097494 | regulation of vesicle size |
| Biological Process | GO:1904645 | response to amyloid-beta |
| Biological Process | GO:0016185 | synaptic vesicle budding from presynaptic endocytic zone membrane |
| Biological Process | GO:0048488 | synaptic vesicle endocytosis |
| Biological Process | GO:0099050 | vesicle scission |
Reference
[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.
[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.