Search Results
Overview
| Uniprot ID | P21579 |
|---|---|
| Protein Name | Synaptotagmin-1 |
| Gene Name | SYT1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 105 | GKNAINMKDVKDLGK |
| 190 | KVFLLPDKKKKFETK |
| 201 | FETKVHRKTLNPVFN |
| 237 | YDFDRFSKHDIIGEF |
| 298 | TVVILEAKNLKKMDV |
Function
Calcium sensor that participates in triggering neurotransmitter release at the synapse (By similarity). May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse (By similarity). It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2. Plays a role in dendrite formation by melanocytes (PubMed:23999003)
Protein Sequence
10
MVSESHHEAL
20
AAPPVTTVAT
30
VLPSNATEPA
40
SPGEGKEDAF
50
SKLKEKFMNE
60
LHKIPLPPWA
70
LIAIAIVAVL
80
LVLTCCFCIC
90
KKCLFKKKNK
100
KKGKEKGGKN
110
AINMKDVKDL
120
GKTMKDQALK
130
DDDAETGLTD
140
GEEKEEPKEE
150
EKLGKLQYSL
160
DYDFQNNQLL
170
VGIIQAAELP
180
ALDMGGTSDP
190
YVKVFLLPDK
200
KKKFETKVHR
210
KTLNPVFNEQ
220
FTFKVPYSEL
230
GGKTLVMAVY
240
DFDRFSKHDI
250
IGEFKVPMNT
260
VDFGHVTEEW
270
RDLQSAEKEE
280
QEKLGDICFS
290
LRYVPTAGKL
300
TVVILEAKNL
310
KKMDVGGLSD
320
PYVKIHLMQN
330
GKRLKKKKTT
340
IKKNTLNPYY
350
NESFSFEVPF
360
EQIQKVQVVV
370
TVLDYDKIGK
380
NDAIGKVFVG
390
YNSTGAELRH
400
WSDMLANPRR
410
PIAQWHTLQV
420
EEEVDAMLAV
KK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0030424 | axon |
| Cellular Component | GO:0042584 | chromaffin granule membrane |
| Cellular Component | GO:0030669 | clathrin-coated endocytic vesicle membrane |
| Cellular Component | GO:0060201 | clathrin-sculpted acetylcholine transport vesicle membrane |
| Cellular Component | GO:0061202 | clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane |
| Cellular Component | GO:0060203 | clathrin-sculpted glutamate transport vesicle membrane |
| Cellular Component | GO:0070083 | clathrin-sculpted monoamine transport vesicle membrane |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0031045 | dense core granule |
| Cellular Component | GO:0060076 | excitatory synapse |
| Cellular Component | GO:0070382 | exocytic vesicle |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0005794 | Golgi apparatus |
| Cellular Component | GO:0098686 | hippocampal mossy fiber to CA3 synapse |
| Cellular Component | GO:0043005 | neuron projection |
| Cellular Component | GO:0044306 | neuron projection terminus |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0099524 | postsynaptic cytosol |
| Cellular Component | GO:0014069 | postsynaptic density |
| Cellular Component | GO:0045211 | postsynaptic membrane |
| Cellular Component | GO:0048786 | presynaptic active zone |
| Cellular Component | GO:0099523 | presynaptic cytosol |
| Cellular Component | GO:0042734 | presynaptic membrane |
| Cellular Component | GO:0008021 | synaptic vesicle |
| Cellular Component | GO:0030672 | synaptic vesicle membrane |
| Molecular Function | GO:0005509 | calcium ion binding |
| Molecular Function | GO:0061891 | calcium ion sensor activity |
| Molecular Function | GO:0005544 | calcium-dependent phospholipid binding |
| Molecular Function | GO:0048306 | calcium-dependent protein binding |
| Molecular Function | GO:0005516 | calmodulin binding |
| Molecular Function | GO:0030276 | clathrin binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0008289 | lipid binding |
| Molecular Function | GO:0050750 | low-density lipoprotein particle receptor binding |
| Molecular Function | GO:0140693 | molecular condensate scaffold activity |
| Molecular Function | GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding |
| Molecular Function | GO:0001786 | phosphatidylserine binding |
| Molecular Function | GO:0005543 | phospholipid binding |
| Molecular Function | GO:0046982 | protein heterodimerization activity |
| Molecular Function | GO:0000149 | SNARE binding |
| Molecular Function | GO:0017075 | syntaxin-1 binding |
| Molecular Function | GO:0030348 | syntaxin-3 binding |
| Biological Process | GO:0061588 | calcium activated phospholipid scrambling |
| Biological Process | GO:0099502 | calcium-dependent activation of synaptic vesicle fusion |
| Biological Process | GO:0030154 | cell differentiation |
| Biological Process | GO:0071277 | cellular response to calcium ion |
| Biological Process | GO:0007268 | chemical synaptic transmission |
| Biological Process | GO:0005513 | detection of calcium ion |
| Biological Process | GO:0098746 | fast, calcium ion-dependent exocytosis of neurotransmitter |
| Biological Process | GO:0060080 | inhibitory postsynaptic potential |
| Biological Process | GO:0140694 | membraneless organelle assembly |
| Biological Process | GO:0046929 | negative regulation of neurotransmitter secretion |
| Biological Process | GO:0007269 | neurotransmitter secretion |
| Biological Process | GO:1903235 | positive regulation of calcium ion-dependent exocytosis of neurotransmitter |
| Biological Process | GO:1903861 | positive regulation of dendrite extension |
| Biological Process | GO:0033603 | positive regulation of dopamine secretion |
| Biological Process | GO:0050806 | positive regulation of synaptic transmission |
| Biological Process | GO:0051291 | protein heterooligomerization |
| Biological Process | GO:0051205 | protein insertion into membrane |
| Biological Process | GO:0017158 | regulation of calcium ion-dependent exocytosis |
| Biological Process | GO:0150037 | regulation of calcium-dependent activation of synaptic vesicle fusion |
| Biological Process | GO:0030100 | regulation of endocytosis |
| Biological Process | GO:0017157 | regulation of exocytosis |
| Biological Process | GO:1903305 | regulation of regulated secretory pathway |
| Biological Process | GO:0051966 | regulation of synaptic transmission, glutamatergic |
| Biological Process | GO:2000300 | regulation of synaptic vesicle exocytosis |
| Biological Process | GO:0036465 | synaptic vesicle recycling |
| Biological Process | GO:0048278 | vesicle docking |
| Biological Process | GO:0006906 | vesicle fusion |
| Biological Process | GO:0016050 | vesicle organization |
| Biological Process | GO:0006903 | vesicle targeting |
| Biological Process | GO:0016192 | vesicle-mediated transport |
| Biological Process | GO:0006855 | xenobiotic transmembrane transport |
Reference
[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.