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Overview

Uniprot IDP21670
Protein NameProteasome subunit alpha type-4
Gene NamePsma4
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
199 LAVKVLNKTMDVSKL
210 VSKLSAEKVEIATLT

Function

Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex)

Protein Sequence

10 MSRRYDSRTT 20 IFSPEGRLYQ 30 VEYAMEAIGH 40 AGTCLGILAN 50 DGVLLAAERR 60 NIHKLLDEVF 70 FSEKIYKLNE 80 DMACSVAGIT 90 SDANVLTNEL 100 RLIAQRYLLQ 110 YQEPIPCEQL 120 VTALCDIKQA 130 YTQFGGKRPF 140 GVSLLYIGWD 150 KHYGFQLYQS 160 DPSGNYGGWK 170 ATCIGNNSAA 180 AVSMLKQDYK 190 EGEMTLKSAL 200 ALAVKVLNKT 210 MDVSKLSAEK 220 VEIATLTREN 230 GKTVIRVLKQ 240 KEVEQLIKKH 250 EEEEAKAERE 260 KKEKEQREKD K

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Biological Process GO:0010498 proteasomal protein catabolic process
Biological Process GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
Biological Process GO:0061136 regulation of proteasomal protein catabolic process
Biological Process GO:0006979 response to oxidative stress
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0000932 P-body
Cellular Component GO:0000502 proteasome complex
Cellular Component GO:0005839 proteasome core complex
Cellular Component GO:0019773 proteasome core complex, alpha-subunit complex
Cellular Component GO:0008021 synaptic vesicle

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.

[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.