Search Results
Overview
| Uniprot ID | P21695 |
|---|---|
| Protein Name | Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic |
| Gene Name | GPD1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 106 | GKICDQLKGHLKANA |
| 110 | DQLKGHLKANATGIS |
| 120 | ATGISLIKGVDEGPN |
| 169 | CETTIGCKDPAQGQL |
| 272 | CYGGRNRKVAEAFAR |
| 282 | EAFARTGKSIEQLEK |
| 296 | KELLNGQKLQGPETA |
| 313 | LYSILQHKGLVDKFP |
| 49 | EEDIGGKKLTEIINT |
| 5 | ***MASKKVCIVGSG |
| 62 | NTQHENVKYLPGHKL |
Function
Has glycerol-3-phosphate dehydrogenase activity
Protein Sequence
10
MASKKVCIVG
20
SGNWGSAIAK
30
IVGGNAAQLA
40
QFDPRVTMWV
50
FEEDIGGKKL
60
TEIINTQHEN
70
VKYLPGHKLP
80
PNVVAVPDVV
90
QAAEDADILI
100
FVVPHQFIGK
110
ICDQLKGHLK
120
ANATGISLIK
130
GVDEGPNGLK
140
LISEVIGERL
150
GIPMSVLMGA
160
NIASEVADEK
170
FCETTIGCKD
180
PAQGQLLKEL
190
MQTPNFRITV
200
VQEVDTVEIC
210
GALKNVVAVG
220
AGFCDGLGFG
230
DNTKAAVIRL
240
GLMEMIAFAK
250
LFCSGPVSSA
260
TFLESCGVAD
270
LITTCYGGRN
280
RKVAEAFART
290
GKSIEQLEKE
300
LLNGQKLQGP
310
ETARELYSIL
320
QHKGLVDKFP
330
LFMAVYKVCY
340
EGQPVGEFIH
CLQNHPEHM
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070062 | extracellular exosome |
| Molecular Function | GO:0141152 | glycerol-3-phosphate dehydrogenase (NAD+) activity |
| Molecular Function | GO:0047952 | glycerol-3-phosphate dehydrogenase [NAD(P)+] activity |
| Molecular Function | GO:0051287 | NAD binding |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Biological Process | GO:0005975 | carbohydrate metabolic process |
| Biological Process | GO:0046168 | glycerol-3-phosphate catabolic process |
| Biological Process | GO:0006072 | glycerol-3-phosphate metabolic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.