Search Results
Overview
| Uniprot ID | P21707 |
|---|---|
| Protein Name | Synaptotagmin-1 |
| Gene Name | Syt1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 104 | GKNAINMKDVKDLGK |
| 114 | KDLGKTMKDQALKDD |
| 189 | KVFLLPDKKKKFETK |
| 196 | KKKKFETKVHRKTLN |
| 200 | FETKVHRKTLNPVFN |
| 236 | YDFDRFSKHDIIGEF |
| 267 | RDLQSAEKEEQEKLG |
| 301 | LEAKNLKKMDVGGLS |
| 98 | KGKEKGGKNAINMKD |
Function
Calcium sensor that participates in triggering neurotransmitter release at the synapse (PubMed:2333096, PubMed:30107533). May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2. Plays a role in dendrite formation by melanocytes
Protein Sequence
10
MVSASHPEAL
20
AAPVTTVATL
30
VPHNATEPAS
40
PGEGKEDAFS
50
KLKQKFMNEL
60
HKIPLPPWAL
70
IAIAIVAVLL
80
VVTCCFCVCK
90
KCLFKKKNKK
100
KGKEKGGKNA
110
INMKDVKDLG
120
KTMKDQALKD
130
DDAETGLTDG
140
EEKEEPKEEE
150
KLGKLQYSLD
160
YDFQNNQLLV
170
GIIQAAELPA
180
LDMGGTSDPY
190
VKVFLLPDKK
200
KKFETKVHRK
210
TLNPVFNEQF
220
TFKVPYSELG
230
GKTLVMAVYD
240
FDRFSKHDII
250
GEFKVPMNTV
260
DFGHVTEEWR
270
DLQSAEKEEQ
280
EKLGDICFSL
290
RYVPTAGKLT
300
VVILEAKNLK
310
KMDVGGLSDP
320
YVKIHLMQNG
330
KRLKKKKTTI
340
KKNTLNPYYN
350
ESFSFEVPFE
360
QIQKVQVVVT
370
VLDYDKIGKN
380
DAIGKVFVGY
390
NSTGAELRHW
400
SDMLANPRRP
410
IAQWHTLQVE
420
EEVDAMLAVK
K
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0030424 | axon |
| Cellular Component | GO:0042584 | chromaffin granule membrane |
| Biological Process | GO:0031338 | regulation of vesicle fusion |
| Biological Process | GO:0051592 | response to calcium ion |
| Biological Process | GO:0061669 | spontaneous neurotransmitter secretion |
| Biological Process | GO:0016079 | synaptic vesicle exocytosis |
| Biological Process | GO:0036465 | synaptic vesicle recycling |
| Biological Process | GO:0071911 | synchronous neurotransmitter secretion |
| Biological Process | GO:0048278 | vesicle docking |
| Biological Process | GO:0006906 | vesicle fusion |
| Biological Process | GO:0016050 | vesicle organization |
| Biological Process | GO:0006903 | vesicle targeting |
| Biological Process | GO:0016192 | vesicle-mediated transport |
| Biological Process | GO:0006855 | xenobiotic transmembrane transport |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0031045 | dense core granule |
| Cellular Component | GO:0060076 | excitatory synapse |
| Cellular Component | GO:0070382 | exocytic vesicle |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0005794 | Golgi apparatus |
| Cellular Component | GO:0098686 | hippocampal mossy fiber to CA3 synapse |
| Cellular Component | GO:0043005 | neuron projection |
| Cellular Component | GO:0044306 | neuron projection terminus |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0099524 | postsynaptic cytosol |
| Cellular Component | GO:0014069 | postsynaptic density |
| Cellular Component | GO:0045211 | postsynaptic membrane |
| Cellular Component | GO:0048786 | presynaptic active zone |
| Cellular Component | GO:0099523 | presynaptic cytosol |
| Cellular Component | GO:0042734 | presynaptic membrane |
| Cellular Component | GO:0030141 | secretory granule |
| Cellular Component | GO:0008021 | synaptic vesicle |
| Cellular Component | GO:0030672 | synaptic vesicle membrane |
| Cellular Component | GO:0043195 | terminal bouton |
| Molecular Function | GO:0005509 | calcium ion binding |
| Molecular Function | GO:0061891 | calcium ion sensor activity |
| Molecular Function | GO:0005544 | calcium-dependent phospholipid binding |
| Molecular Function | GO:0048306 | calcium-dependent protein binding |
| Molecular Function | GO:0005516 | calmodulin binding |
| Molecular Function | GO:0030276 | clathrin binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0008289 | lipid binding |
| Molecular Function | GO:0050750 | low-density lipoprotein particle receptor binding |
| Molecular Function | GO:0140693 | molecular condensate scaffold activity |
| Molecular Function | GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding |
| Molecular Function | GO:0001786 | phosphatidylserine binding |
| Molecular Function | GO:0005543 | phospholipid binding |
| Molecular Function | GO:0046982 | protein heterodimerization activity |
| Molecular Function | GO:0000149 | SNARE binding |
| Molecular Function | GO:0019905 | syntaxin binding |
| Molecular Function | GO:0017075 | syntaxin-1 binding |
| Molecular Function | GO:0030348 | syntaxin-3 binding |
| Biological Process | GO:0061588 | calcium activated phospholipid scrambling |
| Biological Process | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter |
| Biological Process | GO:0099502 | calcium-dependent activation of synaptic vesicle fusion |
| Biological Process | GO:0017156 | calcium-ion regulated exocytosis |
| Biological Process | GO:0030154 | cell differentiation |
| Biological Process | GO:0071277 | cellular response to calcium ion |
| Biological Process | GO:0005513 | detection of calcium ion |
| Biological Process | GO:0098746 | fast, calcium ion-dependent exocytosis of neurotransmitter |
| Biological Process | GO:0060080 | inhibitory postsynaptic potential |
| Biological Process | GO:0140694 | membraneless organelle assembly |
| Biological Process | GO:0046929 | negative regulation of neurotransmitter secretion |
| Biological Process | GO:0007269 | neurotransmitter secretion |
| Biological Process | GO:0045956 | positive regulation of calcium ion-dependent exocytosis |
| Biological Process | GO:1903235 | positive regulation of calcium ion-dependent exocytosis of neurotransmitter |
| Biological Process | GO:1903861 | positive regulation of dendrite extension |
| Biological Process | GO:0033603 | positive regulation of dopamine secretion |
| Biological Process | GO:0050806 | positive regulation of synaptic transmission |
| Biological Process | GO:0031340 | positive regulation of vesicle fusion |
| Biological Process | GO:0051291 | protein heterooligomerization |
| Biological Process | GO:0051205 | protein insertion into membrane |
| Biological Process | GO:0017158 | regulation of calcium ion-dependent exocytosis |
| Biological Process | GO:0150037 | regulation of calcium-dependent activation of synaptic vesicle fusion |
| Biological Process | GO:0014059 | regulation of dopamine secretion |
| Biological Process | GO:0030100 | regulation of endocytosis |
| Biological Process | GO:1903305 | regulation of regulated secretory pathway |
| Biological Process | GO:0051966 | regulation of synaptic transmission, glutamatergic |
| Biological Process | GO:2000300 | regulation of synaptic vesicle exocytosis |
Reference
[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.
[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.