Search Results
Overview
| Uniprot ID | P21796 |
|---|---|
| Protein Name | Non-selective voltage-gated ion channel VDAC1 |
| Gene Name | VDAC1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 109 | SFSPNTGKKNAKIKT |
| 110 | FSPNTGKKNAKIKTG |
| 12 | PTYADLGKSARDVFT |
| 197 | FGGSIYQKVNKKLET |
| 20 | SARDVFTKGYGFGLI |
| 201 | IYQKVNKKLETAVNL |
| 224 | TRFGIAAKYQIDPDA |
| 252 | LGYTQTLKPGIKLTL |
| 266 | LSALLDGKNVNAGGH |
| 274 | NVNAGGHKLGLGLEF |
| 34 | IKLDLKTKSENGLEF |
| 61 | VTGSLETKYRWTEYG |
| 96 | DQLARGLKLTFDSSF |
Function
Non-selective voltage-gated ion channel that mediates the transport of anions and cations through the mitochondrion outer membrane and plasma membrane (PubMed:10661876, PubMed:11845315, PubMed:18755977, PubMed:30061676, PubMed:8420959). The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis (PubMed:10661876, PubMed:11845315, PubMed:18755977, PubMed:8420959). It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV (PubMed:10661876, PubMed:18755977, PubMed:8420959). The open state has a weak anion selectivity whereas the closed state is cation-selective (PubMed:18755977, PubMed:8420959). Binds various signaling molecules, including the sphingolipid ceramide, the phospholipid phosphatidylcholine, and the sterols cholesterol and oxysterol (PubMed:18755977, PubMed:31015432). In depolarized mitochondria, acts downstream of PRKN and PINK1 to promote mitophagy or prevent apoptosis; polyubiquitination by PRKN promotes mitophagy, while monoubiquitination by PRKN decreases mitochondrial calcium influx which ultimately inhibits apoptosis (PubMed:32047033). May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis (PubMed:15033708, PubMed:25296756). May mediate ATP export from cells (PubMed:30061676). Part of a complex composed of HSPA9, ITPR1 and VDAC1 that regulates mitochondrial calcium-dependent apoptosis by facilitating calcium transport from the ER lumen to the mitochondria intermembrane space thus providing calcium for the downstream calcium channel MCU that directly releases it into mitochondria matrix (By similarity). Mediates cytochrome c efflux (PubMed:20230784)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0045121 | membrane raft |
| Cellular Component | GO:0031966 | mitochondrial membrane |
| Cellular Component | GO:0042645 | mitochondrial nucleoid |
| Cellular Component | GO:0005741 | mitochondrial outer membrane |
| Cellular Component | GO:0005757 | mitochondrial permeability transition pore complex |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0046930 | pore complex |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0097001 | ceramide binding |
| Molecular Function | GO:0015485 | cholesterol binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0008142 | oxysterol binding |
| Molecular Function | GO:0031210 | phosphatidylcholine binding |
| Molecular Function | GO:0015288 | porin activity |
| Molecular Function | GO:0019901 | protein kinase binding |
| Molecular Function | GO:0044325 | transmembrane transporter binding |
| Molecular Function | GO:0008308 | voltage-gated monoatomic anion channel activity |
| Molecular Function | GO:0005244 | voltage-gated monoatomic ion channel activity |
| Biological Process | GO:0006915 | apoptotic process |
| Biological Process | GO:0036444 | calcium import into the mitochondrion |
| Biological Process | GO:0030855 | epithelial cell differentiation |
| Biological Process | GO:0006869 | lipid transport |
| Biological Process | GO:1990542 | mitochondrial transmembrane transport |
| Biological Process | GO:0006820 | monoatomic anion transport |
| Biological Process | GO:0043066 | negative regulation of apoptotic process |
| Biological Process | GO:0110099 | negative regulation of calcium import into the mitochondrion |
| Biological Process | GO:2000378 | negative regulation of reactive oxygen species metabolic process |
| Biological Process | GO:1901526 | positive regulation of mitophagy |
| Biological Process | GO:1905091 | positive regulation of type 2 mitophagy |
| Biological Process | GO:0042866 | pyruvate biosynthetic process |
| Biological Process | GO:1903146 | regulation of autophagy of mitochondrion |
Reference
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