Overview
| Uniprot ID | P21807 |
|---|
| Protein Name | Peripherin |
|---|
| Gene Name | Prph |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 287 |
AEEWYKSKYADLSDA |
Function
Class-III neuronal intermediate filament protein (PubMed:2624740, PubMed:3339087). My form an independent structural network without the involvement of other neurofilaments or may cooperate with the neuronal intermediate filament proteins NEFL, NEFH, NEFM and INA to form a filamentous network (By similarity). Assembly of the neuronal intermediate filaments may be regulated by RAB7A (By similarity). Plays a role in the development of unmyelinated sensory neurons (By similarity). May be involved in axon elongation and axon regeneration after injury (PubMed:2585054, PubMed:7530776). Inhibits neurite extension in type II spiral ganglion neurons in the cochlea (By similarity)
Protein Sequence
10
MSHHSSGLRS
20
SISSTSYRRT
30
FGPPPSLSPG
40
AFSYSSSSRF
50
SSSRLLGSGS
60
PSSSARLGSF
70
RAPRAGALRL
80
PSERLDFSMA
90
EALNQEFLAT
100
RSNEKQELQE
110
LNDRFANFIE
120
KVRFLEQQNA
130
ALRGELSQAR
140
GQEPARADQL
150
CQQELRELRR
160
ELELLGRERD
170
RVQVERDGLA
180
EDLGALKQRL
190
EEETRKREDA
200
EHNLVLFRKD
210
VDDATLSRLE
220
LERKIESLMD
230
EIEFLKKLHE
240
EELRDLQVSV
250
ESQQVQQVEV
260
EATVKPELTA
270
ALRDIRAQYE
280
NIAAKNLQEA
290
EEWYKSKYAD
300
LSDAANRNHE
310
ALRQAKQEMN
320
ESRRQIQSLT
330
CEVDGLRGTN
340
EALLRQLREL
350
EEQFALEAGG
360
YQAGAARLEE
370
ELRQLKEEMA
380
RHLREYQELL
390
NVKMALDIEI
400
ATYRKLLEGE
410
ESRISVPVHS
420
FASLSLKTTV
430
PEVEPPQDSH
440
SRKMVLIRTI
450
ETRDGEKVVT
460
ESQKEQHSEL
DKSSIHSY
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0043195 |
terminal bouton |
| Cellular Component |
GO:0030424 |
axon |
| Cellular Component |
GO:0044299 |
C-fiber |
| Cellular Component |
GO:0005882 |
intermediate filament |
| Cellular Component |
GO:0005883 |
neurofilament |
| Cellular Component |
GO:0043025 |
neuronal cell body |
| Cellular Component |
GO:0043204 |
perikaryon |
| Cellular Component |
GO:0001750 |
photoreceptor outer segment |
| Cellular Component |
GO:0042622 |
photoreceptor outer segment membrane |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Cellular Component |
GO:0045098 |
type III intermediate filament |
| Molecular Function |
GO:0044877 |
protein-containing complex binding |
| Molecular Function |
GO:0005200 |
structural constituent of cytoskeleton |
| Biological Process |
GO:0045104 |
intermediate filament cytoskeleton organization |
| Biological Process |
GO:0045109 |
intermediate filament organization |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.