Search Results

Overview

Uniprot ID	P21912
Protein Name	Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Gene Name	SDHB
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
233	FTEERLAKLQDPFSL
261	PKGLNPGKAIAEIKK
274	KKMMATYKEKKASV*
80	LDALIKIKNEVDSTL

Function

Iron-sulfur protein (IP) subunit of the succinate dehydrogenase complex (mitochondrial respiratory chain complex II), responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (PubMed:26925370, PubMed:27604842). SDH also oxidizes malate to the non-canonical enol form of oxaloacetate, enol-oxaloacetate (By similarity). Enol-oxaloacetate, which is a potent inhibitor of the succinate dehydrogenase activity, is further isomerized into keto-oxaloacetate (By similarity)

Protein Sequence

10 MAAVVALSLR 20 RRLPATTLGG 30 ACLQASRGAQ 40 TAAATAPRIK 50 KFAIYRWDPD 60 KAGDKPHMQT 70 YEVDLNKCGP 80 MVLDALIKIK 90 NEVDSTLTFR 100 RSCREGICGS 110 CAMNINGGNT 120 LACTRRIDTN 130 LNKVSKIYPL 140 PHMYVIKDLV 150 PDLSNFYAQY 160 KSIEPYLKKK 170 DESQEGKQQY 180 LQSIEEREKL 190 DGLYECILCA 200 CCSTSCPSYW 210 WNGDKYLGPA 220 VLMQAYRWMI 230 DSRDDFTEER 240 LAKLQDPFSL 250 YRCHTIMNCT 260 RTCPKGLNPG 270 KAIAEIKKMM 280 ATYKEKKASV

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005743	mitochondrial inner membrane
Cellular Component	GO:0005759	mitochondrial matrix
Cellular Component	GO:0031966	mitochondrial membrane
Cellular Component	GO:0005739	mitochondrion
Cellular Component	GO:0045273	respiratory chain complex II (succinate dehydrogenase)
Molecular Function	GO:0051537	2 iron, 2 sulfur cluster binding
Molecular Function	GO:0051538	3 iron, 4 sulfur cluster binding
Molecular Function	GO:0051539	4 iron, 4 sulfur cluster binding
Molecular Function	GO:0009055	electron transfer activity
Molecular Function	GO:0046872	metal ion binding
Molecular Function	GO:0008177	succinate dehydrogenase (quinone) activity
Molecular Function	GO:0048039	ubiquinone binding
Biological Process	GO:0009060	aerobic respiration
Biological Process	GO:0006121	mitochondrial electron transport, succinate to ubiquinone
Biological Process	GO:0042776	proton motive force-driven mitochondrial ATP synthesis
Biological Process	GO:0022904	respiratory electron transport chain
Biological Process	GO:0006105	succinate metabolic process
Biological Process	GO:0006099	tricarboxylic acid cycle

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.