Search Results
Overview
| Uniprot ID | P21913 |
|---|---|
| Protein Name | Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial |
| Gene Name | Sdhb |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 64 | KPRMQTYKVDLNKCG |
| 69 | TYKVDLNKCGPMVLD |
Function
Iron-sulfur protein (IP) subunit of the succinate dehydrogenase complex (mitochondrial respiratory chain complex II), responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (By similarity). SDH also oxidizes malate to the non-canonical enol form of oxaloacetate, enol-oxaloacetate. Enol-oxaloacetate, which is a potent inhibitor of the succinate dehydrogenase activity, is further isomerized into keto-oxaloacetate (By similarity)
Protein Sequence
10
MAAVVGVSLK
20
RGFSATALGR
30
VGLQFQACRE
40
AQTAAAAAPR
50
IKTFAIYRWD
60
PDKAGDKPRM
70
QTYKVDLNKC
80
GPMVLDALIK
90
IKNEIDSTLT
100
FRRSCREGIC
110
GSCAMNINGG
120
NTLACTRRID
130
TDLGKVSKIY
140
PLPHMYVIKD
150
LVPDLSNFYA
160
QYKSIEPYLK
170
KKDESQEGKQ
180
QYLQSIEDRE
190
KLDGLYECIL
200
CACCSTSCPS
210
YWWNGDKYLG
220
PAVLMQAYRW
230
MIDSRDEFTE
240
ERLAKLQDPF
250
SLYRCHTIMN
260
CTQTCPKGLN
270
PGKAIAEIKK
280
MMATYKEKRA
LA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005743 | mitochondrial inner membrane |
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0031966 | mitochondrial membrane |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0045273 | respiratory chain complex II (succinate dehydrogenase) |
| Molecular Function | GO:0051537 | 2 iron, 2 sulfur cluster binding |
| Molecular Function | GO:0051538 | 3 iron, 4 sulfur cluster binding |
| Molecular Function | GO:0051539 | 4 iron, 4 sulfur cluster binding |
| Molecular Function | GO:0009055 | electron transfer activity |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0008177 | succinate dehydrogenase (quinone) activity |
| Molecular Function | GO:0048039 | ubiquinone binding |
| Biological Process | GO:0009060 | aerobic respiration |
| Biological Process | GO:0006121 | mitochondrial electron transport, succinate to ubiquinone |
| Biological Process | GO:0042776 | proton motive force-driven mitochondrial ATP synthesis |
| Biological Process | GO:0022904 | respiratory electron transport chain |
| Biological Process | GO:0006105 | succinate metabolic process |
| Biological Process | GO:0006099 | tricarboxylic acid cycle |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.