Search Results
Overview
| Uniprot ID | P21926 |
|---|---|
| Protein Name | CD9 antigen |
| Gene Name | CD9 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 126 | KEVQEFYKDTYNKLK |
| 131 | FYKDTYNKLKTKDEP |
| 170 | ISDICPKKDVLETFT |
Function
Integral membrane protein associated with integrins, which regulates different processes, such as sperm-egg fusion, platelet activation and aggregation, and cell adhesion (PubMed:14575715, PubMed:18541721, PubMed:8478605). Present at the cell surface of oocytes and plays a key role in sperm-egg fusion, possibly by organizing multiprotein complexes and the morphology of the membrane required for the fusion (By similarity). In myoblasts, associates with CD81 and PTGFRN and inhibits myotube fusion during muscle regeneration (By similarity). In macrophages, associates with CD81 and beta-1 and beta-2 integrins, and prevents macrophage fusion into multinucleated giant cells specialized in ingesting complement-opsonized large particles (PubMed:12796480). Also prevents the fusion between mononuclear cell progenitors into osteoclasts in charge of bone resorption (By similarity). Acts as a receptor for PSG17 (By similarity). Involved in platelet activation and aggregation (PubMed:18541721). Regulates paranodal junction formation (By similarity). Involved in cell adhesion, cell motility and tumor metastasis (PubMed:7511626, PubMed:8478605)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Biological Process | GO:0014003 | oligodendrocyte development |
| Cellular Component | GO:0016324 | apical plasma membrane |
| Cellular Component | GO:0030669 | clathrin-coated endocytic vesicle membrane |
| Cellular Component | GO:0030666 | endocytic vesicle membrane |
| Cellular Component | GO:0009897 | external side of plasma membrane |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:1903561 | extracellular vesicle |
| Cellular Component | GO:0005925 | focal adhesion |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0031092 | platelet alpha granule membrane |
| Cellular Component | GO:0032991 | protein-containing complex |
| Molecular Function | GO:0005178 | integrin binding |
| Biological Process | GO:0007155 | cell adhesion |
| Biological Process | GO:0071404 | cellular response to low-density lipoprotein particle stimulus |
| Biological Process | GO:0007342 | fusion of sperm to egg plasma membrane involved in single fertilization |
| Biological Process | GO:0008347 | glial cell migration |
| Biological Process | GO:0014905 | myoblast fusion involved in skeletal muscle regeneration |
| Biological Process | GO:0090331 | negative regulation of platelet aggregation |
| Biological Process | GO:0030913 | paranodal junction assembly |
| Biological Process | GO:0030168 | platelet activation |
| Biological Process | GO:0031623 | receptor internalization |
| Biological Process | GO:1905521 | regulation of macrophage migration |
| Biological Process | GO:0035036 | sperm-egg recognition |
Reference
[1] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.
[2] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.
[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.