Search Results
Overview
| Uniprot ID | P21964 |
|---|---|
| Protein Name | Catechol O-methyltransferase |
| Gene Name | COMT |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 159 | MVDFAGVKDKVTLVV |
| 177 | QDIIPQLKKKYDVDT |
| 95 | WAMNVGDKKGKIVDA |
Function
Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol
Protein Sequence
10
MPEAPPLLLA
20
AVLLGLVLLV
30
VLLLLLRHWG
40
WGLCLIGWNE
50
FILQPIHNLL
60
MGDTKEQRIL
70
NHVLQHAEPG
80
NAQSVLEAID
90
TYCEQKEWAM
100
NVGDKKGKIV
110
DAVIQEHQPS
120
VLLELGAYCG
130
YSAVRMARLL
140
SPGARLITIE
150
INPDCAAITQ
160
RMVDFAGVKD
170
KVTLVVGASQ
180
DIIPQLKKKY
190
DVDTLDMVFL
200
DHWKDRYLPD
210
TLLLEECGLL
220
RKGTVLLADN
230
VICPGAPDFL
240
AHVRGSSCFE
250
CTHYQSFLEY
260
REVVDGLEKA
270
IYKGPGSEAG
P
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0030424 | axon |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0016206 | catechol O-methyltransferase activity |
| Molecular Function | GO:0000287 | magnesium ion binding |
| Molecular Function | GO:0008168 | methyltransferase activity |
| Molecular Function | GO:0008171 | O-methyltransferase activity |
| Biological Process | GO:0042424 | catecholamine catabolic process |
| Biological Process | GO:0032502 | developmental process |
| Biological Process | GO:0042420 | dopamine catabolic process |
| Biological Process | GO:0042417 | dopamine metabolic process |
| Biological Process | GO:0006629 | lipid metabolic process |
| Biological Process | GO:0032259 | methylation |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0030425 | dendrite |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.