Search Results

Overview

Uniprot ID	P22033
Protein Name	Methylmalonyl-CoA mutase, mitochondrial
Gene Name	MMUT
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
121	STVEESNKFYKDNIK
212	EQGVPKEKLTGTIQN
595	RQEFGESKEITSAIK
602	KEITSAIKRVHKFME

Function

Catalyzes the reversible isomerization of methylmalonyl-CoA (MMCoA) (generated from branched-chain amino acid metabolism and degradation of dietary odd chain fatty acids and cholesterol) to succinyl-CoA (3-carboxypropionyl-CoA), a key intermediate of the tricarboxylic acid cycle

Protein Sequence

10 MLRAKNQLFL 20 LSPHYLRQVK 30 ESSGSRLIQQ 40 RLLHQQQPLH 50 PEWAALAKKQ 60 LKGKNPEDLI 70 WHTPEGISIK 80 PLYSKRDTMD 90 LPEELPGVKP 100 FTRGPYPTMY 110 TFRPWTIRQY 120 AGFSTVEESN 130 KFYKDNIKAG 140 QQGLSVAFDL 150 ATHRGYDSDN 160 PRVRGDVGMA 170 GVAIDTVEDT 180 KILFDGIPLE 190 KMSVSMTMNG 200 AVIPVLANFI 210 VTGEEQGVPK 220 EKLTGTIQND 230 ILKEFMVRNT 240 YIFPPEPSMK 250 IIADIFEYTA 260 KHMPKFNSIS 270 ISGYHMQEAG 280 ADAILELAYT 290 LADGLEYSRT 300 GLQAGLTIDE 310 FAPRLSFFWG 320 IGMNFYMEIA 330 KMRAGRRLWA 340 HLIEKMFQPK 350 NSKSLLLRAH 360 CQTSGWSLTE 370 QDPYNNIVRT 380 AIEAMAAVFG 390 GTQSLHTNSF 400 DEALGLPTVK 410 SARIARNTQI 420 IIQEESGIPK 430 VADPWGGSYM 440 MECLTNDVYD 450 AALKLINEIE 460 EMGGMAKAVA 470 EGIPKLRIEE 480 CAARRQARID 490 SGSEVIVGVN 500 KYQLEKEDAV 510 EVLAIDNTSV 520 RNRQIEKLKK 530 IKSSRDQALA 540 ERCLAALTEC 550 AASGDGNILA 560 LAVDASRARC 570 TVGEITDALK 580 KVFGEHKAND 590 RMVSGAYRQE 600 FGESKEITSA 610 IKRVHKFMER 620 EGRRPRLLVA 630 KMGQDGHDRG 640 AKVIATGFAD 650 LGFDVDIGPL 660 FQTPREVAQQ 670 AVDADVHAVG 680 ISTLAAGHKT 690 LVPELIKELN 700 SLGRPDILVM 710 CGGVIPPQDY 720 EFLFEVGVSN 730 VFGPGTRIPK 740 AAVQVLDDIE 750 KCLEKKQQSV

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005759	mitochondrial matrix
Cellular Component	GO:0005739	mitochondrion
Molecular Function	GO:0031419	cobalamin binding
Molecular Function	GO:0003924	GTPase activity
Molecular Function	GO:0042802	identical protein binding
Molecular Function	GO:0046872	metal ion binding
Molecular Function	GO:0004494	methylmalonyl-CoA mutase activity
Molecular Function	GO:0072341	modified amino acid binding
Molecular Function	GO:0042803	protein homodimerization activity
Biological Process	GO:0050667	homocysteine metabolic process
Biological Process	GO:0043547	positive regulation of GTPase activity
Biological Process	GO:0019678	propionate metabolic process, methylmalonyl pathway
Biological Process	GO:1901290	succinyl-CoA biosynthetic process

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.