Search Results

Overview

Uniprot IDP22102
Protein NameTrifunctional purine biosynthetic protein adenosine-3
Gene NameGART
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
129 AQWKAFTKPEEACSF
156 ASGLAAGKGVIVAKS
251 NDLLLKIKDTVLQRT
28 LAQSHHVKQVLVAPG
453 AGNMLVKKIQPLAKA
499 GTDGVGTKLKIAQLC
501 DGVGTKLKIAQLCNK
866 PTRVINHKLYKNRVE
977 ATLSERVKLAEHKIF

Function

Trifunctional enzyme that catalyzes three distinct reactions as part of the 'de novo' inosine monophosphate biosynthetic pathway

Protein Sequence

10 MAARVLIIGS 20 GGREHTLAWK 30 LAQSHHVKQV 40 LVAPGNAGTA 50 CSEKISNTAI 60 SISDHTALAQ 70 FCKEKKIEFV 80 VVGPEAPLAA 90 GIVGNLRSAG 100 VQCFGPTAEA 110 AQLESSKRFA 120 KEFMDRHGIP 130 TAQWKAFTKP 140 EEACSFILSA 150 DFPALVVKAS 160 GLAAGKGVIV 170 AKSKEEACKA 180 VQEIMQEKAF 190 GAAGETIVIE 200 ELLDGEEVSC 210 LCFTDGKTVA 220 PMPPAQDHKR 230 LLEGDGGPNT 240 GGMGAYCPAP 250 QVSNDLLLKI 260 KDTVLQRTVD 270 GMQQEGTPYT 280 GILYAGIMLT 290 KNGPKVLEFN 300 CRFGDPECQV 310 ILPLLKSDLY 320 EVIQSTLDGL 330 LCTSLPVWLE 340 NHTALTVVMA 350 SKGYPGDYTK 360 GVEITGFPEA 370 QALGLEVFHA 380 GTALKNGKVV 390 THGGRVLAVT 400 AIRENLISAL 410 EEAKKGLAAI 420 KFEGAIYRKD 430 VGFRAIAFLQ 440 QPRSLTYKES 450 GVDIAAGNML 460 VKKIQPLAKA 470 TSRSGCKVDL 480 GGFAGLFDLK 490 AAGFKDPLLA 500 SGTDGVGTKL 510 KIAQLCNKHD 520 TIGQDLVAMC 530 VNDILAQGAE 540 PLFFLDYFSC 550 GKLDLSVTEA 560 VVAGIAKACG 570 KAGCALLGGE 580 TAEMPDMYPP 590 GEYDLAGFAV 600 GAMERDQKLP 610 HLERITEGDV 620 VVGIASSGLH 630 SNGFSLVRKI 640 VAKSSLQYSS 650 PAPDGCGDQT 660 LGDLLLTPTR 670 IYSHSLLPVL 680 RSGHVKAFAH 690 ITGGGLLENI 700 PRVLPEKLGV 710 DLDAQTWRIP 720 RVFSWLQQEG 730 HLSEEEMART 740 FNCGVGAVLV 750 VSKEQTEQIL 760 RDIQQHKEEA 770 WVIGSVVARA 780 EGSPRVKVKN 790 LIESMQINGS 800 VLKNGSLTNH 810 FSFEKKKARV 820 AVLISGTGSN 830 LQALIDSTRE 840 PNSSAQIDIV 850 ISNKAAVAGL 860 DKAERAGIPT 870 RVINHKLYKN 880 RVEFDSAIDL 890 VLEEFSIDIV 900 CLAGFMRILS 910 GPFVQKWNGK 920 MLNIHPSLLP 930 SFKGSNAHEQ 940 ALETGVTVTG 950 CTVHFVAEDV 960 DAGQIILQEA 970 VPVKRGDTVA 980 TLSERVKLAE 990 HKIFPAALQL 1000 VASGTVQLGE 1010 NGKICWVKEE

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0046872 metal ion binding
Molecular Function GO:0004637 phosphoribosylamine-glycine ligase activity
Molecular Function GO:0004641 phosphoribosylformylglycinamidine cyclo-ligase activity
Molecular Function GO:0004644 phosphoribosylglycinamide formyltransferase activity
Biological Process GO:0044208 'de novo' AMP biosynthetic process
Biological Process GO:0006189 'de novo' IMP biosynthetic process
Biological Process GO:0097294 'de novo' XMP biosynthetic process
Biological Process GO:0046084 adenine biosynthetic process
Biological Process GO:0003360 brainstem development
Biological Process GO:0021549 cerebellum development
Biological Process GO:0021987 cerebral cortex development
Biological Process GO:0006177 GMP biosynthetic process
Biological Process GO:0006164 purine nucleotide biosynthetic process
Biological Process GO:0009168 purine ribonucleoside monophosphate biosynthetic process

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.