Search Results

Overview

Uniprot IDP22307
Protein NameSterol carrier protein 2
Gene NameSCP2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
126 LGFEKMSKGSLGIKF
132 SKGSLGIKFSDRTIP
142 DRTIPTDKHVDLLIN
168 QMFGYAGKEHMEKYG
173 AGKEHMEKYGTKIEH
177 HMEKYGTKIEHFAKI
183 TKIEHFAKIGWKNHK
190 KIGWKNHKHSVNNPY
274 FEEKSIIKMVGFDMS
282 MVGFDMSKEAARKCY
341 GDNTYGGKWVINPSG
432 SSASDGFKANLVFKE
438 FKANLVFKEIEKKLE
44 DLAEEAGKKALADAQ
443 VFKEIEKKLEEEGEQ
453 EEGEQFVKKIGGIFA
454 EGEQFVKKIGGIFAF
464 GIFAFKVKDGPGGKE
470 VKDGPGGKEATWVVD
482 VVDVKNGKGSVLPNS
491 SVLPNSDKKADCTIT
492 VLPNSDKKADCTITM
522 QSAFFQGKLKITGNM
524 AFFQGKLKITGNMGL
546 QLQPGNAKL******

Function

Plays a crucial role in the peroxisomal oxidation of branched-chain fatty acids (PubMed:10706581). Catalyzes the last step of the peroxisomal beta-oxidation of branched chain fatty acids and the side chain of the bile acid intermediates di- and trihydroxycoprostanic acids (DHCA and THCA) (PubMed:10706581). Also active with medium and long straight chain 3-oxoacyl-CoAs. Stimulates the microsomal conversion of 7-dehydrocholesterol to cholesterol and transfers phosphatidylcholine and 7-dehydrocholesterol between membrances, in vitro (By similarity). Isoforms SCP2 and SCPx cooperate in peroxisomal oxidation of certain naturally occurring tetramethyl-branched fatty acyl-CoAs (By similarity)

Protein Sequence

10 MSSSPWEPAT 20 LRRVFVVGVG 30 MTKFVKPGAE 40 NSRDYPDLAE 50 EAGKKALADA 60 QIPYSAVDQA 70 CVGYVFGDST 80 CGQRAIYHSL 90 GMTGIPIINV 100 NNNCATGSTA 110 LFMARQLIQG 120 GVAECVLALG 130 FEKMSKGSLG 140 IKFSDRTIPT 150 DKHVDLLINK 160 YGLSAHPVAP 170 QMFGYAGKEH 180 MEKYGTKIEH 190 FAKIGWKNHK 200 HSVNNPYSQF 210 QDEYSLDEVM 220 ASKEVFDFLT 230 ILQCCPTSDG 240 AAAAILASEA 250 FVQKYGLQSK 260 AVEILAQEMM 270 TDLPSSFEEK 280 SIIKMVGFDM 290 SKEAARKCYE 300 KSGLTPNDID 310 VIELHDCFST 320 NELLTYEALG 330 LCPEGQGATL 340 VDRGDNTYGG 350 KWVINPSGGL 360 ISKGHPLGAT 370 GLAQCAELCW 380 QLRGEAGKRQ 390 VPGAKVALQH 400 NLGIGGAVVV 410 TLYKMGFPEA 420 ASSFRTHQIE 430 AVPTSSASDG 440 FKANLVFKEI 450 EKKLEEEGEQ 460 FVKKIGGIFA 470 FKVKDGPGGK 480 EATWVVDVKN 490 GKGSVLPNSD 500 KKADCTITMA 510 DSDFLALMTG 520 KMNPQSAFFQ 530 GKLKITGNMG 540 LAMKLQNLQL QPGNAKL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005783 endoplasmic reticulum
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0016020 membrane
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0005782 peroxisomal matrix
Cellular Component GO:0005777 peroxisome
Cellular Component GO:0032991 protein-containing complex
Molecular Function GO:0003988 acetyl-CoA C-acyltransferase activity
Molecular Function GO:0050633 acetyl-CoA C-myristoyltransferase activity
Molecular Function GO:0015485 cholesterol binding
Molecular Function GO:0120020 cholesterol transfer activity
Molecular Function GO:0000062 fatty-acyl-CoA binding
Molecular Function GO:0036042 long-chain fatty acyl-CoA binding
Molecular Function GO:0070538 oleic acid binding
Molecular Function GO:0120019 phosphatidylcholine transfer activity
Molecular Function GO:0008526 phosphatidylinositol transfer activity
Molecular Function GO:0033814 propanoyl-CoA C-acyltransferase activity
Molecular Function GO:0050632 propionyl-CoA C2-trimethyltridecanoyltransferase activity
Molecular Function GO:0005102 signaling receptor binding
Biological Process GO:0036109 alpha-linolenic acid metabolic process
Biological Process GO:0006699 bile acid biosynthetic process
Biological Process GO:0008206 bile acid metabolic process
Biological Process GO:0006635 fatty acid beta-oxidation
Biological Process GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase
Biological Process GO:0006633 fatty acid biosynthetic process
Biological Process GO:0032959 inositol trisphosphate biosynthetic process
Biological Process GO:0032367 intracellular cholesterol transport
Biological Process GO:1901373 lipid hydroperoxide transport
Biological Process GO:0015914 phospholipid transport
Biological Process GO:0032385 positive regulation of intracellular cholesterol transport
Biological Process GO:0045940 positive regulation of steroid metabolic process
Biological Process GO:0006701 progesterone biosynthetic process
Biological Process GO:0072659 protein localization to plasma membrane
Biological Process GO:0019216 regulation of lipid metabolic process
Biological Process GO:0071071 regulation of phospholipid biosynthetic process
Biological Process GO:0006694 steroid biosynthetic process

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.