Overview
| Uniprot ID | P22310 |
|---|
| Protein Name | UDP-glucuronosyltransferase 1A4 |
|---|
| Gene Name | UGT1A4 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 108 |
FETEHLLKRYSRSMA |
| 70 |
PEVNMHIKEEKFFTL |
Function
UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:18177842, PubMed:24641623, PubMed:15231852). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:18177842, PubMed:20133892). Involved in the glucuronidation of calcidiol, which is the major circulating form of vitamin D3 essential for the regulation of calcium and phosphate homeostasis (PubMed:24641623). Also glucuronidates the biologically active form of vitamin D3, calcitriol, probably leading to its biliary transport and intestinal reabsorption (PubMed:18177842). Involved in the glucuronidation of arachidonic acid (AA) and AA-derived eicosanoids including 15-HETE, 20-HETE and PGB1 (PubMed:15231852). Catalyzes N-glucuronidation of tobacco alkaloids, tobacco-specific nitrosamines and tricyclic antidepressants (PubMed:17576790, PubMed:18238858, PubMed:20133892, PubMed:28803208)
Protein Sequence
10
MARGLQVPLP
20
RLATGLLLLL
30
SVQPWAESGK
40
VLVVPTDGSP
50
WLSMREALRE
60
LHARGHQAVV
70
LTPEVNMHIK
80
EEKFFTLTAY
90
AVPWTQKEFD
100
RVTLGYTQGF
110
FETEHLLKRY
120
SRSMAIMNNV
130
SLALHRCCVE
140
LLHNEALIRH
150
LNATSFDVVL
160
TDPVNLCGAV
170
LAKYLSIPAV
180
FFWRYIPCDL
190
DFKGTQCPNP
200
SSYIPKLLTT
210
NSDHMTFLQR
220
VKNMLYPLAL
230
SYICHTFSAP
240
YASLASELFQ
250
REVSVVDLVS
260
YASVWLFRGD
270
FVMDYPRPIM
280
PNMVFIGGIN
290
CANGKPLSQE
300
FEAYINASGE
310
HGIVVFSLGS
320
MVSEIPEKKA
330
MAIADALGKI
340
PQTVLWRYTG
350
TRPSNLANNT
360
ILVKWLPQND
370
LLGHPMTRAF
380
ITHAGSHGVY
390
ESICNGVPMV
400
MMPLFGDQMD
410
NAKRMETKGA
420
GVTLNVLEMT
430
SEDLENALKA
440
VINDKSYKEN
450
IMRLSSLHKD
460
RPVEPLDLAV
470
FWVEFVMRHK
480
GAPHLRPAAH
490
DLTWYQYHSL
500
DVIGFLLAVV
510
LTVAFITFKC
520
CAYGYRKCLG
530
KKGRVKKAHK
SKTH
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005783 |
endoplasmic reticulum |
| Cellular Component |
GO:0005789 |
endoplasmic reticulum membrane |
| Molecular Function |
GO:0019899 |
enzyme binding |
| Molecular Function |
GO:0004857 |
enzyme inhibitor activity |
| Molecular Function |
GO:0015020 |
glucuronosyltransferase activity |
| Molecular Function |
GO:0046982 |
protein heterodimerization activity |
| Molecular Function |
GO:0042803 |
protein homodimerization activity |
| Molecular Function |
GO:0008194 |
UDP-glycosyltransferase activity |
| Biological Process |
GO:0006789 |
bilirubin conjugation |
| Biological Process |
GO:0071385 |
cellular response to glucocorticoid stimulus |
| Biological Process |
GO:0008210 |
estrogen metabolic process |
| Biological Process |
GO:0051552 |
flavone metabolic process |
| Biological Process |
GO:0019585 |
glucuronate metabolic process |
| Biological Process |
GO:0042167 |
heme catabolic process |
| Biological Process |
GO:0001889 |
liver development |
| Biological Process |
GO:0045922 |
negative regulation of fatty acid metabolic process |
| Biological Process |
GO:0016125 |
sterol metabolic process |
| Biological Process |
GO:0070640 |
vitamin D3 metabolic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.