Search Results
Overview
| Uniprot ID | P22315 |
|---|---|
| Protein Name | Ferrochelatase, mitochondrial |
| Gene Name | Fech |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 117 | IAKRRTPKIQEQYRR |
| 56 | VHHAKTTKPQAQPER |
Function
Catalyzes the ferrous insertion into protoporphyrin IX
Protein Sequence
10
MLSASANMAA
20
ALRAAGALLR
30
EPLVHGSSRA
40
CQPWRCQSGA
50
AVAATTEKVH
60
HAKTTKPQAQ
70
PERRKPKTGI
80
LMLNMGGPET
90
LGEVQDFLQR
100
LFLDRDLMTL
110
PIQNKLAPFI
120
AKRRTPKIQE
130
QYRRIGGGSP
140
IKMWTSKQGE
150
GMVKLLDELS
160
PATAPHKYYI
170
GFRYVHPLTE
180
EAIEEMERDG
190
LERAIAFTQY
200
PQYSCSTTGS
210
SLNAIYRYYN
220
EVGQKPTMKW
230
STIDRWPTHP
240
LLIQCFADHI
250
LKELNHFPEE
260
KRSEVVILFS
270
AHSLPMSVVN
280
RGDPYPQEVG
290
ATVHKVMEKL
300
GYPNPYRLVW
310
QSKVGPVPWL
320
GPQTDEAIKG
330
LCERGRKNIL
340
LVPIAFTSDH
350
IETLYELDIE
360
YSQVLAQKCG
370
AENIRRAESL
380
NGNPLFSKAL
390
ADLVHSHIQS
400
NKLCSTQLSL
410
NCPLCVNPVC
420
RKTKSFFTSQ
QL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0043190 | ATP-binding cassette (ABC) transporter complex |
| Cellular Component | GO:0005743 | mitochondrial inner membrane |
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0031966 | mitochondrial membrane |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0051537 | 2 iron, 2 sulfur cluster binding |
| Molecular Function | GO:0004325 | ferrochelatase activity |
| Molecular Function | GO:0020037 | heme binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0005506 | iron ion binding |
| Molecular Function | GO:0030350 | iron-responsive element binding |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0046906 | tetrapyrrole binding |
| Biological Process | GO:0008203 | cholesterol metabolic process |
| Biological Process | GO:0009589 | detection of UV |
| Biological Process | GO:0030218 | erythrocyte differentiation |
| Biological Process | GO:0006784 | heme A biosynthetic process |
| Biological Process | GO:0006785 | heme B biosynthetic process |
| Biological Process | GO:0006783 | heme biosynthetic process |
| Biological Process | GO:0060586 | multicellular organismal-level iron ion homeostasis |
| Biological Process | GO:0006779 | porphyrin-containing compound biosynthetic process |
| Biological Process | GO:0046501 | protoporphyrinogen IX metabolic process |
| Biological Process | GO:0010999 | regulation of eIF2 alpha phosphorylation by heme |
| Biological Process | GO:0046984 | regulation of hemoglobin biosynthetic process |
| Biological Process | GO:0009416 | response to light stimulus |
| Biological Process | GO:0034379 | very-low-density lipoprotein particle assembly |
Reference
[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.
[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.