Search Results
Overview
| Uniprot ID | P22492 |
|---|---|
| Protein Name | Histone H1t |
| Gene Name | H1-6 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 191 | KARASKSKLTQHHEV |
Function
Testis-specific histone H1 that forms less compacted chromatin compared to other H1 histone subtypes (PubMed:26757249). Formation of more relaxed chromatin may be required to promote chromatin architecture required for proper chromosome regulation during meiosis, such as homologous recombination (PubMed:26757249). Histones H1 act as linkers that bind to nucleosomes and compact polynucleosomes into a higher-order chromatin configuration (Probable)
Protein Sequence
10
MSETVPAASA
20
SAGVAAMEKL
30
PTKKRGRKPA
40
GLISASRKVP
50
NLSVSKLITE
60
ALSVSQERVG
70
MSLVALKKAL
80
AAAGYDVEKN
90
NSRIKLSLKS
100
LVNKGILVQT
110
RGTGASGSFK
120
LSKKVIPKST
130
RSKAKKSVSA
140
KTKKLVLSRD
150
SKSPKTAKTN
160
KRAKKPRATT
170
PKTVRSGRKA
180
KGAKGKQQQK
190
SPVKARASKS
200
KLTQHHEVNV
RKATSKK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0000786 | nucleosome |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0003690 | double-stranded DNA binding |
| Molecular Function | GO:0031492 | nucleosomal DNA binding |
| Molecular Function | GO:0030527 | structural constituent of chromatin |
| Biological Process | GO:0030154 | cell differentiation |
| Biological Process | GO:0030261 | chromosome condensation |
| Biological Process | GO:0045910 | negative regulation of DNA recombination |
| Biological Process | GO:0006334 | nucleosome assembly |
| Biological Process | GO:0007283 | spermatogenesis |
Reference
PMID: N/A