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Overview

Uniprot ID	P22570
Protein Name	NADPH:adrenodoxin oxidoreductase, mitochondrial
Gene Name	FDXR
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
209	LERTDITKAALGVLR
267	LGLQDKIKEVPRPRK
376	PSVPFDSKLGVIPNV

Function

Serves as the first electron transfer protein in all the mitochondrial P450 systems including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver (By similarity). Also acts as a ferredoxin--NADP(+) reductase essential for coenzyme Q biosynthesis: together with FDX2, transfers the electrons required for the hydroxylation reaction performed by COQ6 (PubMed:38425362)

Protein Sequence

10 MASRCWRWWG 20 WSAWPRTRLP 30 PAGSTPSFCH 40 HFSTQEKTPQ 50 ICVVGSGPAG 60 FYTAQHLLKH 70 PQAHVDIYEK 80 QPVPFGLVRF 90 GVAPDHPEVK 100 NVINTFTQTA 110 HSGRCAFWGN 120 VEVGRDVTVP 130 ELREAYHAVV 140 LSYGAEDHRA 150 LEIPGEELPG 160 VCSARAFVGW 170 YNGLPENQEL 180 EPDLSCDTAV 190 ILGQGNVALD 200 VARILLTPPE 210 HLERTDITKA 220 ALGVLRQSRV 230 KTVWLVGRRG 240 PLQVAFTIKE 250 LREMIQLPGA 260 RPILDPVDFL 270 GLQDKIKEVP 280 RPRKRLTELL 290 LRTATEKPGP 300 AEAARQASAS 310 RAWGLRFFRS 320 PQQVLPSPDG 330 RRAAGVRLAV 340 TRLEGVDEAT 350 RAVPTGDMED 360 LPCGLVLSSI 370 GYKSRPVDPS 380 VPFDSKLGVI 390 PNVEGRVMDV 400 PGLYCSGWVK 410 RGPTGVIATT 420 MTDSFLTGQM 430 LLQDLKAGLL 440 PSGPRPGYAA 450 IQALLSSRGV 460 RPVSFSDWEK 470 LDAEEVARGQ 480 GTGKPREKLV 490 DPQEMLRLLG H

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005743	mitochondrial inner membrane
Cellular Component	GO:0005759	mitochondrial matrix
Cellular Component	GO:0005739	mitochondrion
Molecular Function	GO:0004324	ferredoxin-NADP+ reductase activity
Biological Process	GO:0008203	cholesterol metabolic process
Biological Process	GO:0006124	ferredoxin metabolic process
Biological Process	GO:0006091	generation of precursor metabolites and energy
Biological Process	GO:0006694	steroid biosynthetic process
Biological Process	GO:0006744	ubiquinone biosynthetic process

Reference

[1] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[2] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.