Search Results
Overview
| Uniprot ID | P22612 |
|---|---|
| Protein Name | cAMP-dependent protein kinase catalytic subunit gamma |
| Gene Name | PRKACG |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 293 | RNGVGDIKNHKWFAT |
| 296 | VGDIKNHKWFATTSW |
| 309 | SWIAIYEKKVEAPFI |
Function
Phosphorylates a large number of substrates in the cytoplasm and the nucleus
Protein Sequence
10
MGNAPAKKDT
20
EQEESVNEFL
30
AKARGDFLYR
40
WGNPAQNTAS
50
SDQFERLRTL
60
GMGSFGRVML
70
VRHQETGGHY
80
AMKILNKQKV
90
VKMKQVEHIL
100
NEKRILQAID
110
FPFLVKLQFS
120
FKDNSYLYLV
130
MEYVPGGEMF
140
SRLQRVGRFS
150
EPHACFYAAQ
160
VVLAVQYLHS
170
LDLIHRDLKP
180
ENLLIDQQGY
190
LQVTDFGFAK
200
RVKGRTWTLC
210
GTPEYLAPEI
220
ILSKGYNKAV
230
DWWALGVLIY
240
EMAVGFPPFY
250
ADQPIQIYEK
260
IVSGRVRFPS
270
KLSSDLKHLL
280
RSLLQVDLTK
290
RFGNLRNGVG
300
DIKNHKWFAT
310
TSWIAIYEKK
320
VEAPFIPKYT
330
GPGDASNFDD
340
YEEEELRISI
350
NEKCAKEFSE
F
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005952 | cAMP-dependent protein kinase complex |
| Cellular Component | GO:0097546 | ciliary base |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0004691 | cAMP-dependent protein kinase activity |
| Molecular Function | GO:0019870 | potassium channel inhibitor activity |
| Molecular Function | GO:0034237 | protein kinase A regulatory subunit binding |
| Molecular Function | GO:0106310 | protein serine kinase activity |
| Molecular Function | GO:0004674 | protein serine/threonine kinase activity |
| Biological Process | GO:0007189 | adenylate cyclase-activating G protein-coupled receptor signaling pathway |
| Biological Process | GO:0034380 | high-density lipoprotein particle assembly |
| Biological Process | GO:0008584 | male gonad development |
| Biological Process | GO:0032024 | positive regulation of insulin secretion |
| Biological Process | GO:0003091 | renal water homeostasis |
| Biological Process | GO:0007283 | spermatogenesis |
| Biological Process | GO:0097700 | vascular endothelial cell response to laminar fluid shear stress |
Reference
[1] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.