Search Results
Overview
| Uniprot ID | P22760 |
|---|---|
| Protein Name | Arylacetamide deacetylase |
| Gene Name | AADAC |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 175 | LRKKVLAKYGVNPER |
| 293 | LLPERFIKGHVYNNP |
| 310 | GSSELAKKYPGFLDV |
| 328 | PLLADDNKLRGLPLT |
Function
Displays cellular triglyceride lipase activity in liver, increases the levels of intracellular fatty acids derived from the hydrolysis of newly formed triglyceride stores and plays a role in very low-density lipoprotein assembly. Displays serine esterase activity in liver. Deacetylates a variety of arylacetamide substrates, including xenobiotic compounds and procarcinogens, converting them to the primary arylamide compounds and increasing their toxicity
Protein Sequence
10
MGRKSLYLLI
20
VGILIAYYIY
30
TPLPDNVEEP
40
WRMMWINAHL
50
KTIQNLATFV
60
ELLGLHHFMD
70
SFKVVGSFDE
80
VPPTSDENVT
90
VTETKFNNIL
100
VRVYVPKRKS
110
EALRRGLFYI
120
HGGGWCVGSA
130
ALSGYDLLSR
140
WTADRLDAVV
150
VSTNYRLAPK
160
YHFPIQFEDV
170
YNALRWFLRK
180
KVLAKYGVNP
190
ERIGISGDSA
200
GGNLAAAVTQ
210
QLLDDPDVKI
220
KLKIQSLIYP
230
ALQPLDVDLP
240
SYQENSNFLF
250
LSKSLMVRFW
260
SEYFTTDRSL
270
EKAMLSRQHV
280
PVESSHLFKF
290
VNWSSLLPER
300
FIKGHVYNNP
310
NYGSSELAKK
320
YPGFLDVRAA
330
PLLADDNKLR
340
GLPLTYVITC
350
QYDLLRDDGL
360
MYVTRLRNTG
370
VQVTHNHVED
380
GFHGAFSFLG
390
LKISHRLINQ
YIEWLKENL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Molecular Function | GO:0003824 | catalytic activity |
| Molecular Function | GO:0019213 | deacetylase activity |
| Molecular Function | GO:0016298 | lipase activity |
| Molecular Function | GO:0017171 | serine hydrolase activity |
| Molecular Function | GO:0004806 | triacylglycerol lipase activity |
| Biological Process | GO:0006629 | lipid metabolic process |
| Biological Process | GO:0010898 | positive regulation of triglyceride catabolic process |
| Biological Process | GO:0006805 | xenobiotic metabolic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.