Search Results
Overview
| Uniprot ID | P22830 |
|---|---|
| Protein Name | Ferrochelatase, mitochondrial |
| Gene Name | FECH |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 64 | KPQVQPQKRKPKTGI |
Function
Catalyzes the ferrous insertion into protoporphyrin IX and participates in the terminal step in the heme biosynthetic pathway
Protein Sequence
10
MRSLGANMAA
20
ALRAAGVLLR
30
DPLASSSWRV
40
CQPWRWKSGA
50
AAAAVTTETA
60
QHAQGAKPQV
70
QPQKRKPKTG
80
ILMLNMGGPE
90
TLGDVHDFLL
100
RLFLDRDLMT
110
LPIQNKLAPF
120
IAKRRTPKIQ
130
EQYRRIGGGS
140
PIKIWTSKQG
150
EGMVKLLDEL
160
SPNTAPHKYY
170
IGFRYVHPLT
180
EEAIEEMERD
190
GLERAIAFTQ
200
YPQYSCSTTG
210
SSLNAIYRYY
220
NQVGRKPTMK
230
WSTIDRWPTH
240
HLLIQCFADH
250
ILKELDHFPL
260
EKRSEVVILF
270
SAHSLPMSVV
280
NRGDPYPQEV
290
SATVQKVMER
300
LEYCNPYRLV
310
WQSKVGPMPW
320
LGPQTDESIK
330
GLCERGRKNI
340
LLVPIAFTSD
350
HIETLYELDI
360
EYSQVLAKEC
370
GVENIRRAES
380
LNGNPLFSKA
390
LADLVHSHIQ
400
SNELCSKQLT
410
LSCPLCVNPV
420
CRETKSFFTS
QQL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005743 | mitochondrial inner membrane |
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0031966 | mitochondrial membrane |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0051537 | 2 iron, 2 sulfur cluster binding |
| Molecular Function | GO:0004325 | ferrochelatase activity |
| Molecular Function | GO:0008198 | ferrous iron binding |
| Molecular Function | GO:0020037 | heme binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0030350 | iron-responsive element binding |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Biological Process | GO:0006091 | generation of precursor metabolites and energy |
| Biological Process | GO:0006784 | heme A biosynthetic process |
| Biological Process | GO:0006785 | heme B biosynthetic process |
| Biological Process | GO:0006783 | heme biosynthetic process |
| Biological Process | GO:0046501 | protoporphyrinogen IX metabolic process |
| Biological Process | GO:0009416 | response to light stimulus |
Reference
[1] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.